| Evidence for clonal disease by magnetic resonance imaging in patients with hypoplastic marrow disorders. | |
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MedLine Citation:
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PMID: 1954375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Some patients with hypoplastic marrow disorders, including aplastic anemia (AA), are at risk for clonal evolution to myelodysplastic syndromes (MDS) and leukemia. Magnetic resonance imaging (MRI) of marrow of the spine, pelvis, and femurs was performed in 24 patients with hypoplastic marrow disorders. In 12 patients (three AA, nine MDS) MRI was compatible with the clinical and biopsy diagnoses and served to define the spectrum of marrow patterns in these disorders. In eight patients with hypocellular marrow biopsies and a clinical diagnosis of AA, MRI showed an unexpected inhomogeneous or diffuse cellular pattern. Concurrent or subsequent marrow or cytogenetic studies have led to diagnoses of hypoplastic MDS in seven of these patients. In four patients with prolonged hypoplasia after bone marrow transplantation for lymphoma, a speckled pattern superimposed on a fatty background appeared in serial MRI studies. One case evolved to AML, two developed megaloblastic foci, and one remains hypoplastic at 19 months. This study suggests that MRI is able to detect early clonal disease in patients with AA, and can distinguish AA from hypoplastic MDS. |
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Authors:
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W Negendank; D Weissman; T M Bey; M M de Planque; C Karanes; M R Smith; V Ratanatharathorn; C R Bishop; A M al-Katib; L L Sensenbrenner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood Volume: 78 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1991-12-31 Completed Date: 1991-12-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2872-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Harper Hospital, Wayne State University, Detroit, MI. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Aplastic / diagnosis*, pathology Bone Marrow / pathology Clone Cells Female Humans Magnetic Resonance Imaging Male Middle Aged Myelodysplastic Syndromes / diagnosis*, pathology Pancytopenia / diagnosis, pathology Primary Myelofibrosis / diagnosis* |
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