Document Detail

Evidence for clonal attenuation of growth potential in HeLa cells.
MedLine Citation:
PMID:  738739     Owner:  NLM     Status:  MEDLINE    
The growth of primary clones and serial subclones of HeLa cells and of diploid human fibroblast-like cells were compared both in the presence and absence of feeder layers; the latter had no significant effects upon the results. Clones and subclones of both cell types displayed great heterogeneity in growth rates, typically with a bimodality of growth distributions. Serial passages of clones selected on the basis of superior rates of proliferation showed attentuation of growth potentials; the extent of such attentuations was much less in the case of HeLa cells, suggesting at least one possible basis for the differences in long-term growth potential between these two classes of cell lines.
A O Martinez; T H Norwood; J W Prothero; G M Martin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  In vitro     Volume:  14     ISSN:  0073-5655     ISO Abbreviation:  In Vitro     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-04-28     Completed Date:  1979-04-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0063733     Medline TA:  In Vitro     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  996-1002     Citation Subset:  IM    
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MeSH Terms
Cell Division
Clone Cells / cytology
Hela Cells / cytology*

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