Document Detail


Evidence for a circulating sodium transport inhibitor in essential hypertension.
MedLine Citation:
PMID:  6783199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The active sodium transport of white cells and red cells obtained from patients with essential hypertension was impaired. Incubating white cells from normotensive subjects in serum obtained from patients with essential hypertension caused an impairment in sodium transport in the white cells of normotensive subjects similar to that found in the white cells of hypertensive patients. The impairment in sodium transport was due to a fall in the ouabain-sensitive component of the total sodium efflux rate constant. These results show that the serum of patients with essential hypertension contains a substance which influences sodium transport and that it has ouabain-like activity. They also suggest that it is this substance which causes the impairment in sodium transport in the leucocytes of patients with essential hypertension. These findings support the hypothesis that the rise in blood pressure in patients with essential hypertension is due to an increased concentration of a circulating sodium transport inhibitor which is continuously correcting a tendency for sodium retention by the kidney.
Authors:
L Poston; R B Sewell; S P Wilkinson; P J Richardson; R Williams; E M Clarkson; G A MacGregor; H E de Wardener
Related Documents :
10511389 - Potassium in preventing and treating high blood pressure.
10890579 - Natriuretic effect of barnidipine, a long-acting dihydropyridine calcium channel blocke...
3780799 - Influence of intrapelvic pressure on excretion of sodium from human hydronephrotic kidn...
10410299 - A dietary approach to prevent hypertension: a review of the dietary approaches to stop ...
15250919 - Dietary sodium restriction for hypertension in dialysis patients.
3327379 - The kidney: cause or consequence in essential hypertension.
3443949 - Myogenic adaptation of rabbit ear arteries to pulsatile internal pressures.
1308839 - The effects of cassia abbreviata on rat blood pressure.
20530299 - Target blood pressure for treatment of isolated systolic hypertension in the elderly: v...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  282     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  847-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biological Transport, Active
Cells, Cultured
Erythrocytes / metabolism
Female
Humans
Hypertension / blood*
Leukocytes / metabolism
Male
Middle Aged
Peptides*
Sodium / antagonists & inhibitors*,  blood
Chemical
Reg. No./Substance:
0/Peptides; 0/serum sodium transport inhibitor; 7440-23-5/Sodium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Knowledge and experience of young people regarding drug abuse between 1969 and 1979.
Next Document:  Glucose turnover and metabolic and hormonal changes in ethanol-induced hypoglycaemia.