Document Detail

Evidence for a circulating sodium transport inhibitor in essential hypertension.
MedLine Citation:
PMID:  6783199     Owner:  NLM     Status:  MEDLINE    
The active sodium transport of white cells and red cells obtained from patients with essential hypertension was impaired. Incubating white cells from normotensive subjects in serum obtained from patients with essential hypertension caused an impairment in sodium transport in the white cells of normotensive subjects similar to that found in the white cells of hypertensive patients. The impairment in sodium transport was due to a fall in the ouabain-sensitive component of the total sodium efflux rate constant. These results show that the serum of patients with essential hypertension contains a substance which influences sodium transport and that it has ouabain-like activity. They also suggest that it is this substance which causes the impairment in sodium transport in the leucocytes of patients with essential hypertension. These findings support the hypothesis that the rise in blood pressure in patients with essential hypertension is due to an increased concentration of a circulating sodium transport inhibitor which is continuously correcting a tendency for sodium retention by the kidney.
L Poston; R B Sewell; S P Wilkinson; P J Richardson; R Williams; E M Clarkson; G A MacGregor; H E de Wardener
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  282     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  847-9     Citation Subset:  IM    
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MeSH Terms
Biological Transport, Active
Cells, Cultured
Erythrocytes / metabolism
Hypertension / blood*
Leukocytes / metabolism
Middle Aged
Sodium / antagonists & inhibitors*,  blood
Reg. No./Substance:
0/Peptides; 0/serum sodium transport inhibitor; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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