Document Detail


Evidence of chorda tympani dysfunction in patients with burning mouth syndrome.
MedLine Citation:
PMID:  17473041     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: More than two-thirds of patients with burning mouth syndrome (BMS) have altered taste sensation. The authors conducted a study to assess chorda tympani and trigeminal nerve function in these patients. METHODS: The study was composed of 48 patients; 22 were diagnosed as having BMS, 14 had burning symptoms related to other diseases and were diagnosed as having secondary burning mouth syndrome (SBMS), and 12 were healthy volunteers. The authors evaluated the electrical detection thresholds of the infraorbital and mental nerves and the electrical taste and electrical detection/tingling thresholds in the anterior two-thirds of the tongue for all patients. Electrical taste threshold is thought to be dictated by chorda tympani nerve function while electrical detection/tingling thresholds are regulated by trigeminal nerve function. RESULTS: The mean electrical taste/tingling detection thresholds ratio and the taste detection thresholds were significantly higher in patients with BMS than in patients with SBMS and in control subjects, indicating chorda tympani nerve dysfunction. Eighteen (82 percent) of the 22 patients with BMS demonstrated chorda tympani dysfunction (13 unilateral and five bilateral). CONCLUSIONS: Chorda tympani hypofunction may play an important role in BMS pathology. Unilateral hypofunction may be sufficient to produce generalized burning sensation exceeding the affected nerve area. CLINICAL IMPLICATIONS: Elevated taste detection threshold levels determined via electrogustatory testing and an elevated taste/tingling detection thresholds ratio may assist clinicians in the diagnosis of BMS. More studies are needed to validate these findings.
Authors:
Eli Eliav; Batya Kamran; Rachel Schaham; Rakefet Czerninski; Richard H Gracely; Rafael Benoliel
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American Dental Association (1939)     Volume:  138     ISSN:  0002-8177     ISO Abbreviation:  J Am Dent Assoc     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-02     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503060     Medline TA:  J Am Dent Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  628-33     Citation Subset:  D; IM    
Affiliation:
Department of Diagnostic Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. eliavel@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Burning Mouth Syndrome / diagnosis*,  physiopathology
Chin / innervation
Chorda Tympani Nerve / physiopathology*
Electrodiagnosis
Female
Humans
Lingual Nerve / physiopathology
Male
Middle Aged
Orbit / innervation
Paresthesia / physiopathology
Sensory Thresholds / physiology
Taste / physiology
Tongue / innervation
Trigeminal Nerve / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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