Document Detail

Evidence of cholecystokinin release by bombesin in the dog.
MedLine Citation:
PMID:  4451817     Owner:  NLM     Status:  MEDLINE    
1 The intravenous infusion of bombesin elicited in the dog a contraction of the gall bladder with decreased opening pressure of the choledocho-duodenal junction and stimulation of pancreatic secretion.2 The pancreatic juice produced under the influence of bombesin was poor in bicarbonate and rich in protein. Threshold doses of the peptide were of the order of 0.25 mug kg(-1) h(-1) and maximum protein output was obtained with 1 mug kg(-1) h(-1). The pancreatic protein response to bombesin was very similar, in its onset and duration, to that elicited by intraduodenal infusion of L-tryptophan. Infusions of bombesin repeated at short intervals produced tachyphylaxis.3 Antrectomy did not affect the stimulant action of bombesin on the pancreas. Atropine however, reduced the pancreatic protein response to bombesin.4 It is suggested that bombesin acts on the gall bladder and the exocrine pancreas through release of cholecystokinin from the duodenal mucosa. No release of secretion could be demonstrated. It is likely that the releasing activity of bombesin is limited, in the field of gastrointestinal peptides, to those belonging to the gastrin-cholecystokinin family.
V Erspamer; G Improta; P Melchiorri; N Sopranzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  52     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1974 Oct 
Date Detail:
Created Date:  1975-06-12     Completed Date:  1975-06-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
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MeSH Terms
Atropine / pharmacology
Bicarbonates / analysis
Bile / secretion
Blood Pressure / drug effects
Caerulein / pharmacology
Cholecystokinin / metabolism*
Gallbladder / drug effects
Pancreas / drug effects,  secretion
Pancreatic Juice / analysis
Peptides / pharmacology*
Pyloric Antrum / physiology
Stimulation, Chemical
Tissue Extracts / pharmacology*
Tryptophan / pharmacology
Reg. No./Substance:
0/Bicarbonates; 0/Peptides; 0/Tissue Extracts; 17650-98-5/Caerulein; 51-55-8/Atropine; 73-22-3/Tryptophan; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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