Document Detail


Evidence for a cerebral effect of the hepatitis C virus.
MedLine Citation:
PMID:  11454379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with hepatitis C virus (HCV) infection frequently complain of symptoms akin to the chronic fatigue syndrome and score worse on health-related quality of life indices than matched controls. We address the hypothesis that HCV itself affects cerebral function. Using proton magnetic-resonance spectroscopy we have shown elevations in basal ganglia and white matter choline/creatine ratios in patients with histologically-mild hepatitis C, compared with healthy volunteers and patients with hepatitis B. This elevation is unrelated to hepatic encephalopathy or a history of intravenous drug abuse, and suggests that a biological process underlies the extrahepatic symptoms in chronic HCV infection.
Authors:
D M Forton; J M Allsop; J Main; G R Foster; H C Thomas; S D Taylor-Robinson
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  358     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  38-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Basal Ganglia / pathology
Basal Ganglia Diseases / diagnosis*,  pathology
Biopsy
Brain / pathology
Brain Diseases / diagnosis*,  pathology
Choline / metabolism
Creatine / metabolism
Fatigue Syndrome, Chronic / diagnosis*,  pathology
Female
Hepatitis C, Chronic / diagnosis*,  pathology
Humans
Liver / pathology
Magnetic Resonance Spectroscopy*
Male
Middle Aged
Chemical
Reg. No./Substance:
57-00-1/Creatine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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