Document Detail

Evidence for a cerebral effect of the hepatitis C virus.
MedLine Citation:
PMID:  11454379     Owner:  NLM     Status:  MEDLINE    
Patients with hepatitis C virus (HCV) infection frequently complain of symptoms akin to the chronic fatigue syndrome and score worse on health-related quality of life indices than matched controls. We address the hypothesis that HCV itself affects cerebral function. Using proton magnetic-resonance spectroscopy we have shown elevations in basal ganglia and white matter choline/creatine ratios in patients with histologically-mild hepatitis C, compared with healthy volunteers and patients with hepatitis B. This elevation is unrelated to hepatic encephalopathy or a history of intravenous drug abuse, and suggests that a biological process underlies the extrahepatic symptoms in chronic HCV infection.
D M Forton; J M Allsop; J Main; G R Foster; H C Thomas; S D Taylor-Robinson
Related Documents :
20025439 - Knowledge about hepatitis-c among methadone maintenance treatment patients in israel.
18855559 - Genetic markers of igg influence the outcome of infection with hepatitis c virus.
9653489 - Clinico-pathological characterization of hepatitis c virus-related b-cell non-hodgkin's...
12580379 - Molecular characterization of hepatitis c virus (hcv) core region in hcv-infected thai ...
8930439 - Virology of hepatitis c virus.
9342559 - Hepatitis c virus infection in the elderly. epidemiology, prophylaxis and optimal treat...
1308079 - Immune complex levels and hbs-antigenaemia in healthy nigerians and patients with liver...
2841379 - Gastrointestinal viral infections in homosexual men who were symptomatic and seropositi...
16644889 - Haptoglobin polymorphism in a hiv-1 seropositive brazilian population.
Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  358     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  38-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Basal Ganglia / pathology
Basal Ganglia Diseases / diagnosis*,  pathology
Brain / pathology
Brain Diseases / diagnosis*,  pathology
Choline / metabolism
Creatine / metabolism
Fatigue Syndrome, Chronic / diagnosis*,  pathology
Hepatitis C, Chronic / diagnosis*,  pathology
Liver / pathology
Magnetic Resonance Spectroscopy*
Middle Aged
Reg. No./Substance:
57-00-1/Creatine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Emergency treatment of neonatal hyperammonaemic coma with mild systemic hypothermia.
Next Document:  Effects of fenofibrate and gemfibrozil on plasma homocysteine.