Document Detail


Evidence for cellular cooperativity in hemoglobin synthesis by erythroid bursts.
MedLine Citation:
PMID:  7202577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied hemoglobin synthesis associated with erythroid bursts under various conditions. The slope of the curve relating log cell number to log hemoglobin synthesis is consistently greater than the slope of the curve relating log cell number to log bursts, suggesting that cellular interactions may be involved in maximal hemoglobin synthesis by the cells comprising the bursts. This suggestion if strengthened by experiments which show that gentle disruption of burst structure is accompanied by a decline in hemoglobin synthesis.
Authors:
J F Eliason; E Goldwasser
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental hematology     Volume:  8     ISSN:  0301-472X     ISO Abbreviation:  Exp. Hematol.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0402313     Medline TA:  Exp Hematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow / drug effects,  metabolism
Bone Marrow Cells*
Cell Communication
Cell Count
Erythropoietin / pharmacology
Hemoglobins / biosynthesis*
Mice
Time Factors
Grant Support
ID/Acronym/Agency:
CA 19265/CA/NCI NIH HHS; HL 16005/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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