Document Detail


Evidence for a carbachol stimulated phosphatidylinositol effect in heart.
MedLine Citation:
PMID:  7150339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Incubation of canine heart slices with 32P-inorganic phosphate in physiological medium resulted in the incorporation of 32P into a number of cardiac phospholipids. Carbachol, a non-hydrolyzable acetylcholine analogue, selectively increased 32P-incorporation into phosphatidic acid and phosphatidylinositol in slices of right auricle 80 and 70% respectively. This effect of carbachol was half-maximal at 5-10 microM and was inhibited completely by atropine. Carbachol did not affect labeling of other phospholipids in right auricle and did not affect the labeling of any phospholipid in slices of left auricle or right or left ventricle. These results provide evidence for a muscarinic receptor mediated phospholipid effect which appears to be localized in the right atrial region of canine heart.
Authors:
E E Quist
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  31     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3130-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbachol / pharmacology*
Dogs
Female
Heart Atria / metabolism
Heart Ventricles / metabolism
Male
Myocardium / metabolism*
Phosphatidylinositols / metabolism*
Phospholipids / metabolism
Chemical
Reg. No./Substance:
0/Phosphatidylinositols; 0/Phospholipids; 51-83-2/Carbachol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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