Document Detail

Evidence of brain ischemia in early neonatal sudden death syndrome.
MedLine Citation:
PMID:  9266551     Owner:  NLM     Status:  MEDLINE    
Ten early neonatal sudden death victims (ENSD) were selected for neuropathological and immunohistochemical examinations. The gestational ages of the victims ranged from 36 to 42 weeks, and the postnatal ages from 8 hours to 10 days of life. In 6 of 10 patients, softening with rarefaction was observed in the subcortical or intermediate white matter, which was associated with minimal astrogliosis in the whole white matter. In 7 of the 10 ENSD victims, the number of GFAP-positive glia was significantly greater in both the deep and subcortical white matter than in controls. The brainstem showed mild gliosis in the reticular formation and vagal nuclei of the medulla oblongata in 8 of the 10 ENSD victims. In 8 of the 10 ENSD victims, the number of GFAP-positive astrocytes was greater in both the dorsal vagal nucleus and the reticular formation of the medulla oblongata than in controls. The high incidence of leukomalacia and astrogliosis in the cerebral white matter and brainstem suggests the presence of brain ischemic insults before death, which may be prenatal in some cases.
T Obonai; M Asanuma; R Mizuta; H Horie; J Tanaka; S Takashima
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropediatrics     Volume:  28     ISSN:  0174-304X     ISO Abbreviation:  Neuropediatrics     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-10-21     Completed Date:  1997-10-21     Revised Date:  2008-01-16    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  IM    
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
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MeSH Terms
Astrocytes / chemistry
Brain Ischemia / complications,  pathology*
Brain Stem / pathology
Case-Control Studies
Glial Fibrillary Acidic Protein / analysis
Gliosis / pathology
Infant, Newborn
Leukomalacia, Periventricular / pathology
Neural Pathways / pathology
Sudden Infant Death / etiology,  pathology*
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein

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