Document Detail

Evidence-based neonatology: making a difference beyond discharge from the neonatal nursery.
MedLine Citation:
PMID:  11981285     Owner:  NLM     Status:  MEDLINE    
The number of controlled clinical trials in neonatal medicine has increased steadily over recent years. However, most of these trials examine only short-term outcomes during the initial hospital stay. To determine whether a common neonatal intervention does more good than harm, it is important to study its long-term efficacy and safety. This review summarizes randomized trials of neonatal therapies published between October 2000 and September 2001. Only trials that examine outcomes beyond the initial hospital discharge were considered. Four beneficial interventions were identified: promotion of breast-feeding, comprehensive follow-up care for high-risk, very low birthweight infants, cryotherapy for threshold retinopathy of prematurity, and extracorporeal membrane oxygenation for mature infants with severe respiratory failure. Indomethacin prophylaxis in extremely low birthweight infants is of questionable use. Thyroxine supplementation for premature infants and head cooling for asphyxiated term infants require further study and should not be prescribed outside of rigorous clinical trials.
JoAnn Harrold; Barbara Schmidt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  14     ISSN:  1040-8703     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-30     Completed Date:  2002-06-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-9     Citation Subset:  IM    
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Breast Feeding
Cyclooxygenase Inhibitors / therapeutic use
Evidence-Based Medicine*
Extracorporeal Membrane Oxygenation / methods
Indomethacin / therapeutic use
Infant, Low Birth Weight*
Infant, Newborn
Length of Stay*
Neonatology / standards*
Patient Discharge*
Randomized Controlled Trials as Topic / methods,  standards
Research Design
Respiratory Distress Syndrome, Newborn / prevention & control
Retinopathy of Prematurity / prevention & control
Thyroxine / therapeutic use
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 53-86-1/Indomethacin; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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