| Evidence-based medicine: botulinum toxin A in migraine and tension-type headache. | |
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MedLine Citation:
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PMID: 11357239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The therapeutic effect of botulinum toxin in headache was observed coincidentally. The rationale for this new indication initially met with a great deal of scepticism, because the toxin's mechanism of action, cholinergic chemodenervation, does not fit the pathophysiological concept of migraine and other forms of headache. Meanwhile a fair number of studies have been published which indicate efficacy for botulinum toxin and recommend its use for the treatment of tension headache and migraine. According to the evidence-based medicine criteria, grade I evidence has been demonstrated. In addition the use of botulinum toxin for cluster-headache and secondary headache is discussed. Further large scale studies will be regarded to demonstrate the long-term efficacy. |
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Authors:
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H Göbel; A Heinze; K Heinze-Kuhn; W H Jost |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of neurology Volume: 248 Suppl 1 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-05-18 Completed Date: 2001-10-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 34-8 Citation Subset: IM |
Affiliation:
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Kiel Pain Clinic, Heikendorfer Weg 9-27 D-24149 Kiel, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Botulinum Toxin Type A / therapeutic use* Controlled Clinical Trials as Topic / statistics & numerical data Evidence-Based Medicine / statistics & numerical data* Humans Migraine Disorders / drug therapy* Neuromuscular Agents / therapeutic use* Tension-Type Headache / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxin Type A; 0/Neuromuscular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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