| Evidence-based management of ANCA vasculitis. | |
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MedLine Citation:
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PMID: 19508944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The vasculitides associated with antineutrophil cytoplasmic antibodies (ANCAs) present to and are managed by a wide spectrum of physicians, reflecting the multi-organ nature of the conditions. Treatment strategies for these primary inflammatory vascular diseases have varied based on the outcomes of different clinical trials and practice reviews. The individual drugs used and their route of administration, dose, and duration of therapy have varied and have been the source of much debate. Advances in our understanding of disease immunopathogenesis, clinical assessment and outcome have formed the basis for several recent good-quality clinical trials. Now, with the results of these large-scale multicentre collaborative studies, there is a firmer evidence base to guide management decisions for individual patients. This evidence base, reviewed here, has led to the publication of treatment guidelines which importantly encompass many of the broader aspects of disease management. |
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Authors:
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David Carruthers; Jonathan Sherlock |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical rheumatology Volume: 23 ISSN: 1532-1770 ISO Abbreviation: Best Pract Res Clin Rheumatol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-10 Completed Date: 2009-08-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101121149 Medline TA: Best Pract Res Clin Rheumatol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 367-78 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK. david.carruthers@swbh.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antineutrophil Cytoplasmic
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immunology* Clinical Trials as Topic Cyclophosphamide / therapeutic use Drug Therapy, Combination Evidence-Based Medicine Humans Immunosuppressive Agents / therapeutic use* Methotrexate / therapeutic use Practice Guidelines as Topic Remission Induction Vasculitis / immunology*, therapy* Wegener Granulomatosis |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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