Document Detail

Evidence-based correlation between anti-streptolysin O serum titer and sacroiliac joint disorder.
MedLine Citation:
PMID:  17611979     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Poststreptococcal reactive arthritis (PSReA) is a nonsuppurative sequela of antecedent streptococcal infection, and can be investigated when detecting the anti-streptolysin O (ASO) titer. The relationship between ASO titer and involvement of the peripheral synovial joints has been examined in PSRA, but data are sparse for the sacroiliac (SI) joint. Quantitative SI joint scintigraphy has been used clinically to detect active SI joint disorders, but not for PSReA. METHODS: A total of 84 subjects were recruited; mean age at enrollment was 23 years (range 18.0-36.4 yrs). All subjects were examined for ASO titer levels (range 25-520 IU/ml) and SI joint imaging, determined by sacroiliac to sacrum (SI/S) ratio derived from SI scintigraphy. RESULTS: Most of the subjects with high ASO titer had unclassified or undifferentiated arthritis. Good correlation between the ASO titer and the SI/S ratio was determined statistically using Pearson correlation coefficients. The relationships between ASO titer and SI/S ratio at various locations (laterality: left, right; location of part: upper, middle, lower) were found to be significantly correlated using generalized estimating equations. After adjustment for potential confounders, a highly significant association was determined between ASO titer and SI/S ratio (p < 0.0001), with an increase of 1 IU/ml of titer resulting in a significant increase in SI/S ratio by 0.0008 units. Age was significantly associated with SI/S ratio (p = 0.0022), with each extra year increasing the ratio by 0.0074. CONCLUSION: Our findings demonstrate a high correlation between SI joint involvement and high ASO titers. Subjects with SI joint involvement should be advised to have an ASO titer examination and quantitative SI joint scintigraphy.
Shin-Tsu Chang; Chih-Hung Ku; Shiou-Chi Cherng
Related Documents :
18079309 - Dietary l-tyrosine supplementation in nemaline myopathy.
8006559 - Acarboxy prothrombin (pivka-ii) in cord plasma in the south of thailand.
3375909 - Serum vitamin c, vitamin a and carotene values in infants in swa/namibia.
6395059 - Suppression of severe retinopathy of prematurity with vitamin e supplementation. ultras...
18695279 - Antioxidant levels in cord blood of low birth weight newborns.
16363349 - Use of alendronate in the treatment of vitamin d intoxication in infants.
15686249 - Dupuytren's disease in an infant.
20684179 - How to evaluate the child presenting with an apparent life-threatening event?
6197019 - Perinatal mortality--report of a hospital based study.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-01
Journal Detail:
Title:  The Journal of rheumatology     Volume:  34     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1746-52     Citation Subset:  IM    
Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, Medical School, Taipei, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antibodies, Bacterial / blood*
Arthritis, Reactive / blood*,  physiopathology*,  radionuclide imaging
Bacterial Proteins / immunology
Biological Markers / blood
Evidence-Based Medicine
Radionuclide Imaging
Sacroiliac Joint / physiopathology*
Streptococcal Infections / complications*
Streptolysins / immunology*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Biological Markers; 0/Streptolysins; 0/streptolysin O

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physicians' and parents' ratings of inactive disease are frequently discordant in juvenile idiopathi...
Next Document:  The effect of low-dose aspirin on the decreased risk of development of dyspepsia and gastrointestina...