Document Detail

Evidence-based correlation between anti-streptolysin O serum titer and sacroiliac joint disorder.
MedLine Citation:
PMID:  17611979     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Poststreptococcal reactive arthritis (PSReA) is a nonsuppurative sequela of antecedent streptococcal infection, and can be investigated when detecting the anti-streptolysin O (ASO) titer. The relationship between ASO titer and involvement of the peripheral synovial joints has been examined in PSRA, but data are sparse for the sacroiliac (SI) joint. Quantitative SI joint scintigraphy has been used clinically to detect active SI joint disorders, but not for PSReA. METHODS: A total of 84 subjects were recruited; mean age at enrollment was 23 years (range 18.0-36.4 yrs). All subjects were examined for ASO titer levels (range 25-520 IU/ml) and SI joint imaging, determined by sacroiliac to sacrum (SI/S) ratio derived from SI scintigraphy. RESULTS: Most of the subjects with high ASO titer had unclassified or undifferentiated arthritis. Good correlation between the ASO titer and the SI/S ratio was determined statistically using Pearson correlation coefficients. The relationships between ASO titer and SI/S ratio at various locations (laterality: left, right; location of part: upper, middle, lower) were found to be significantly correlated using generalized estimating equations. After adjustment for potential confounders, a highly significant association was determined between ASO titer and SI/S ratio (p < 0.0001), with an increase of 1 IU/ml of titer resulting in a significant increase in SI/S ratio by 0.0008 units. Age was significantly associated with SI/S ratio (p = 0.0022), with each extra year increasing the ratio by 0.0074. CONCLUSION: Our findings demonstrate a high correlation between SI joint involvement and high ASO titers. Subjects with SI joint involvement should be advised to have an ASO titer examination and quantitative SI joint scintigraphy.
Shin-Tsu Chang; Chih-Hung Ku; Shiou-Chi Cherng
Related Documents :
7436479 - Factor x deficiency in the neonatal period.
20404749 - Early diagnosis and treatment of cobalamin deficiency of infancy owing to occult matern...
11338219 - Vitamin k deficiency in diarrhoea.
7647149 - Activities of trypsin and lipase in duodenal aspirates of healthy preterm infants: effe...
2153279 - Deficient herpes simplex virus-induced interferon-alpha production by blood leukocytes ...
998579 - Bulging fontanelle as presenting sign in cystic fibrosis. vitamin a metabolism and effe...
18245409 - Quality of life of formerly preterm and very low birth weight infants from preschool ag...
1741179 - Lack of evidence of efficacy of cohorting nursing personnel in a neonatal intensive car...
11949019 - Intraventricular hemorrhage in the term infant.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-01
Journal Detail:
Title:  The Journal of rheumatology     Volume:  34     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1746-52     Citation Subset:  IM    
Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, Medical School, Taipei, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antibodies, Bacterial / blood*
Arthritis, Reactive / blood*,  physiopathology*,  radionuclide imaging
Bacterial Proteins / immunology
Biological Markers / blood
Evidence-Based Medicine
Radionuclide Imaging
Sacroiliac Joint / physiopathology*
Streptococcal Infections / complications*
Streptolysins / immunology*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Biological Markers; 0/Streptolysins; 0/streptolysin O

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physicians' and parents' ratings of inactive disease are frequently discordant in juvenile idiopathi...
Next Document:  The effect of low-dose aspirin on the decreased risk of development of dyspepsia and gastrointestina...