Document Detail

Evidence base for using corticosteroids to treat HIV-associated immune reconstitution syndrome.
MedLine Citation:
PMID:  16771623     Owner:  NLM     Status:  MEDLINE    
Most of the evidence supporting the use of corticosteroids (steroids) for immune reconstitution syndrome (IRS) comes from case reports or retrospective series and is of low quality. However, when steroids are used, they have usually been associated with clinical improvement or resolution of IRS. Except in the case of hepatitis B- or C-associated IRS, there have been no reports of worsening of the IRS or adverse outcome due to steroid use. After ruling out other conditions which can mimic IRS, clinicians should strongly consider steroids when managing IRS associated with mycobacterial or fungal pathogens when there is severe disease, or when other measures have failed.
Emil Lesho
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of anti-infective therapy     Volume:  4     ISSN:  1744-8336     ISO Abbreviation:  Expert Rev Anti Infect Ther     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101181284     Medline TA:  Expert Rev Anti Infect Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-78     Citation Subset:  IM    
Walter Reed Army Medical Center, Infectious Diseases, 11120 Nicholas Drive, Silver Spring, MD 20902, USA.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use*
CD4 Lymphocyte Count
Cryptococcosis / immunology
HIV Infections / drug therapy*,  immunology*
Leukoencephalopathy, Progressive Multifocal / immunology
Mycobacterium Infections / immunology
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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