Document Detail


Evidence of bacterial biofilms on frontal recess stents in patients with chronic rhinosinusitis.
MedLine Citation:
PMID:  15706985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Bacterial biofilms have been documented on middle ear mucosa, tonsils, and cholesteatoma. We hypothesize that bacterial biofilms are present in mucosa of patients with chronic sinusitis. We believe that frontal sinus stents may serve as a reservoir for biofilms.
EXPERIMENT: We studied silicone frontal sinus stents removed from six patients 1 to 4 weeks after FESS with scanning electron microscopy (SEM).
RESULTS: We identified evidence of bacterial biofilms on the frontal recess stents in six of six patients under SEM. Five of these patients had sinus cultures positive for Staphylococcus aureus. Bacterial biofilms were identified by evidence of glycocalyx, water channels, and three-dimensional structure. These images were similar to other images of known biofilms.
CONCLUSIONS: This is evidence of the possible presence of bacterial biofilms on frontal sinus stents in patients with chronic sinusitis. Further study into the role of bacterial biofilms in perpetuating chronic sinusitis is warranted.
Authors:
Joel R Perloff; James N Palmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of rhinology     Volume:  18     ISSN:  1050-6586     ISO Abbreviation:  Am J Rhinol     Publication Date:    2004 Nov-Dec
Date Detail:
Created Date:  2005-02-14     Completed Date:  2005-05-03     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8807268     Medline TA:  Am J Rhinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-80     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology/Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4206, USA.
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MeSH Terms
Descriptor/Qualifier:
Biofilms / growth & development*
Chronic Disease
Female
Frontal Sinusitis / complications,  microbiology*
Humans
Male
Microscopy, Electron
Silicones
Staphylococcus aureus*
Stents*
Chemical
Reg. No./Substance:
0/Silicones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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