Document Detail

Evidence for atrophy of the corpus callosum in Alzheimer's disease.
MedLine Citation:
PMID:  8174599     Owner:  NLM     Status:  MEDLINE    
Patients with late-onset Alzheimer's disease (AD) have more white matter changes on magnetic resonance imaging (MRI) than controls. To test the hypothesis that AD patients might have also atrophy of the corpus callosum (CC), we compared the CC thickness on MRI from 20 AD patients and 21 controls. We found a significant reduction in the CC thickness in AD compared with age-matched controls (p < 0.01). We demonstrated that atrophy of the CC depends mainly on the diagnosis of senile dementia of the Alzheimer type and at a lower degree on the diagnosis of presenile AD but neither on age nor on ventricle enlargement. This result suggests that beside the greater severity of white matter involvement in late-onset AD, atrophy of the CC may also be present.
P Vermersch; P Scheltens; F Barkhof; M Steinling; D Leys
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European neurology     Volume:  34     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-06-09     Completed Date:  1994-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Department of Neurology, University of Lille, France.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / pathology*
Corpus Callosum / pathology*
Magnetic Resonance Imaging
Middle Aged
Reference Values

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