Document Detail

Evidence for association between insulin resistance and premature carotid atherosclerosis in childhood obesity.
MedLine Citation:
PMID:  17314695     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to determine the presence and predictors of the subclinical atherosclerosis in obese children. Fifty obese children [mean age: 11.7 +/- 2.5 y, mean body mass index (BMI): 28.2 +/- 4.0 kg/m] and 50 age- and sex-matched healthy nonobese controls (mean age: 11.4 +/- 3.73 y, mean BMI: 17.6 +/- 3.0 kg/m) were enrolled in the present study. Oral glucose tolerance test was performed to all obese subjects. Common carotid artery intima-media thickness (IMT) was measured by high-resolution B-mode ultrasonography. Carotid artery IMT was significantly increased (0.0476 +/- 0.007 versus 0.033 +/- 0.011 cm; p < 0.001) in the obese group. There were significant relations between carotid artery IMT and insulin sensitivity indexes derived from fasting samples (fasting glucose to insulin ratio (FGIR; p = 0.004, r = -0.404), quantitative insulin-sensitivity check index (QUICK-I; p = 0.002, r = -0.401) and homeostasis model assessment of insulin resistance (HOMA-IR; p = 0.034, r = 0.300) in the obese group. In a multivariate regression model, QUICK-I emerged as independent correlates for mean IMT in obese children with the total variance explained being 20.7% (beta = -0.58, p < 0.001). We concluded that insulin resistance is an independent risk factor for increased carotid artery IMT in obese children.
Mehmet Emre Atabek; Ozgur Pirgon; Ali Sami Kivrak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  61     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-04-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-9     Citation Subset:  IM    
Selcuk University, Faculty of Medicine, 42080 Konya, Turkey.
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MeSH Terms
Age of Onset
Carotid Arteries / pathology
Carotid Artery Diseases / etiology*,  pathology,  physiopathology*
Case-Control Studies
Glucose Tolerance Test
Insulin / blood
Insulin Resistance / physiology*
Obesity / complications*,  pathology,  physiopathology*
Risk Factors
Reg. No./Substance:

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