Document Detail

Evidence for amino acid concentration gradients between CSF and extracellular fluid.
MedLine Citation:
PMID:  7824195     Owner:  NLM     Status:  MEDLINE    
A small volume in the extracellular space of the medulla in the anesthetized cat was perfused with cisternal cerebrospinal fluid (CSF) using a push-pull technique. The recovered perfusate was a mixture of pushed CSF and the extracellular fluid. HPLC-EC analysis showed that the concentration of some primary amino acids in recovered perfusate often differed from their concentrations in CSF. These results suggested that amino acid gradients existed between CSF and the extracellular space.
V R Roettger; M D Goldfinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  178     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-13     Completed Date:  1995-02-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
Department of Physiology and Biophysics, Wright State University, Dayton, OH 45401-0927.
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MeSH Terms
Amino Acids / cerebrospinal fluid*,  metabolism*
Chromatography, High Pressure Liquid
Electrochemistry / methods
Extracellular Space / metabolism*
Osmolar Concentration
Spinal Cord / metabolism*
Reg. No./Substance:
0/Amino Acids

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