Document Detail

Evidence of alpha-adrenoceptor-mediated chronotropic action in children.
MedLine Citation:
PMID:  11123125     Owner:  NLM     Status:  MEDLINE    
We investigated alpha-adrenoceptor-mediated positive chronotropic action in children using a pharmacological autonomic function test. Under cardiac vagal and sympathetic blockade, chronotropic responses to intravenous infusion of an alpha-agonist, phenylephrine, were determined in 129 patients with suspected autonomic dysfunction. Heart rate changes to phenylephrine infusion (0.4 microg/kg/min) for 5 minutes ranged from -2 to 50 beats/min (mean +/- SD, 13.8 +/- 9.7 beats/min). alpha-Adrenoceptor-mediated chronotropic (APC) action more than 5 beats/min was observed in 88 (68%) subjects. APC was negatively correlated with age. Multivariate analysis showed that APC was correlated negatively with beta-sympathetic tone and positively correlated with intrinsic heart rate. These results suggest that the alpha-adrenoceptor-mediated chronotropic action is a developmental phenomenon and may play an important role in controlling heart rate in response to cardiac sympathetic activation.
H Tanaka; Y Takenaka; H Yamaguchi; M Mino; H Tamai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric cardiology     Volume:  22     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-06-07     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-3     Citation Subset:  IM    
Department of Pediatrics, Osaka Medical College, 2-7, Daigakucho, Takatsuki-shi, Osaka, Japan 569.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Adrenergic alpha-Antagonists / pharmacology
Atropine / pharmacology
Autonomic Nervous System Diseases / physiopathology*
Child, Preschool
Heart Rate / drug effects,  physiology*
Isoproterenol / pharmacology
Multivariate Analysis
Myocardial Contraction / drug effects*
Phentolamine / pharmacology
Phenylephrine / pharmacology
Propranolol / pharmacology
Receptors, Adrenergic, alpha / physiology*
Regression Analysis
Syncope / physiopathology
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha; 50-60-2/Phentolamine; 51-55-8/Atropine; 525-66-6/Propranolol; 59-42-7/Phenylephrine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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