Document Detail


Evidence for alpha-2 adrenoreceptor modulation of arterial chemoreflexes in the caudal solitary nucleus of the rat.
MedLine Citation:
PMID:  11641117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The caudal region of the nucleus of the solitary tract (cNTS) is the primary central termination site for arterial chemoreceptor afferents originating from the carotid body. The purpose of the present study was to investigate the role of endogenous activation of alpha-2 adrenoreceptors in the cNTS on arterial chemoreflex function. Arterial chemoreflex responses to intravenous injections of potassium cyanide (KCN; 75 microg/kg) were recorded before and following blockade of alpha-2 adrenoreceptors in the cNTS of urethane-anesthetized rats. KCN alone elicited a reflex increase in arterial pressure, renal sympathetic nerve activity, and respiration. After bilateral cNTS microinjection of alpha-2 receptor antagonists (2 nmol idazoxan or 0.2 nmol yohimbine), arterial chemoreflex responses were markedly attenuated. Attenuation of chemoreflex function was not accompanied by any significant change in resting blood pressure or respiratory rate. The results suggest that the endogenous activation of alpha-2 adrenoreceptors facilitates central processing of chemoreceptor afferent inputs in the cNTS of the rat.
Authors:
L F Hayward
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  281     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-19     Completed Date:  2001-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1464-73     Citation Subset:  IM    
Affiliation:
Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida 32610-0144, USA. lindah@ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology
Animals
Arteries / cytology,  metabolism*
Blood Pressure / physiology
Carotid Sinus / innervation
Chemoreceptor Cells / metabolism*
Denervation
Excitatory Amino Acid Antagonists / pharmacology
Idazoxan / pharmacology
Kynurenic Acid / pharmacology
Male
Microinjections
Poisons / pharmacology
Potassium Cyanide / pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-2 / antagonists & inhibitors,  metabolism*
Reflex / physiology*
Respiratory Physiological Phenomena
Solitary Nucleus / anatomy & histology,  drug effects,  metabolism*
Vagotomy
Yohimbine / pharmacology
Grant Support
ID/Acronym/Agency:
HL-52607/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Excitatory Amino Acid Antagonists; 0/Poisons; 0/Receptors, Adrenergic, alpha-2; 146-48-5/Yohimbine; 151-50-8/Potassium Cyanide; 492-27-3/Kynurenic Acid; 79944-58-4/Idazoxan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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