| Evidence against a role of arachidonic acid metabolites in autoregulatory responses of the isolated perfused kidney of the rat. | |
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MedLine Citation:
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PMID: 1909958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of arachidonic acid metabolites in renal autoregulatory responses to changes in pressure was examined in rat isolated perfused kidneys. We also studied the influence of diabetes, a condition associated with hyperfiltration and altered renal eicosanoid production, on autoregulatory responses. The perfused rat kidney demonstrated autoregulation of flow within a pressure range of 100-150 mm Hg, with no differences between diabetic and control rat kidneys. Nifedipine resulted in vasodilatation and loss of autoregulation. Inhibition of the cyclooxygenase pathway of arachidonic acid metabolism with indomethacin failed to alter autoregulatory capacity. Similarly, inhibition of lipoxygenase with BW755C or NDGA, or inhibition of cytochrome P450-dependent enzymes with NDGA, clotrimazole or 7-ethoxyresorufin were without effect on autoregulatory responses. In vivo treatment with stannous chloride to deplete renal cytochrome P450-dependent enzymes also failed to modify autoregulatory responses. These results argue against a role of arachidonic acid metabolites in autoregulation of perfusate flow in the isolated kidney. |
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Authors:
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D Sarubbi; J Quilley |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 197 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-10-24 Completed Date: 1991-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 27-31 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, New York Medical College, Valhallo 10595. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
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pharmacology Animals Arachidonic Acid Arachidonic Acids / metabolism, physiology* Blood Pressure / physiology Cytochrome P-450 Enzyme System / antagonists & inhibitors Diabetes Mellitus, Experimental / physiopathology Dinoprostone / metabolism Indomethacin / pharmacology Kidney / physiology* Male Nifedipine / pharmacology Perfusion Rats Rats, Inbred Strains Renal Circulation / physiology Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 21829-25-4/Nifedipine; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 53-86-1/Indomethacin; 66000-40-6/4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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