Document Detail

Evidence against the central nervous system involved in altered reflex control of sympathetic nerve activity by atrial natriuretic peptide.
MedLine Citation:
PMID:  2977304     Owner:  NLM     Status:  MEDLINE    
This study aimed to examine whether atrial natriuretic peptide (ANP) alters arterial baroreceptor control of sympathetic nerve activity (SNA) by acting on the central nervous system (CNS). In rabbits anesthetized with alpha-chloralose, we examined changes in arterial pressure and renal SNA in response to graded electrical stimulation (1.7, 3.3, 5.0 Hz) of aortic depressor nerves during the intravenous (IV) infusion of saline or alpha-human atrial natriuretic peptide (alpha-hANP) (0.1, 1.0 microgram/kg/min) or after the intracerebroventricular (ICV) injections of saline or alpha-hANP (3, 10 micrograms). Sinoaortic denervation and bilateral vagotomy were done before examination in all rabbits to eliminate the influence of the known effects of ANP on arterial and cardiac receptors. IV alpha-hANP decreased arterial pressure but did not alter renal SNA. ICV alpha-hANP did not change arterial pressure or renal SNA. Arterial pressure and renal nerve responses to graded electrical stimulation of aortic depressor nerves were not altered by IV or ICV alpha-hANP. These results suggest that alpha-hANP does not modulate control of renal SNA by acting on CNS.
S Suzuki; A Takeshita; T Imaizumi; Y Hirooka; M Yoshida; M Nakamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  10 Suppl 1     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-30     Completed Date:  1989-05-30     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  263-8     Citation Subset:  IM    
Research Institute of Angiocardiology, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
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MeSH Terms
Aorta / innervation
Atrial Natriuretic Factor / pharmacology*,  physiology
Blood Pressure / drug effects
Brain / physiology*
Kidney / innervation
Pressoreceptors / physiology*
Reflex / physiology*
Sympathetic Nervous System / physiology*
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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