Document Detail

Evidence against the central nervous system being involved in altered reflex control of sympathetic nerve activity by atrial natriuretic peptide.
MedLine Citation:
PMID:  2524239     Owner:  NLM     Status:  MEDLINE    
This study aimed to examine whether atrial natriuretic peptide (ANP) alters arterial baroreceptor control of sympathetic nerve activity (SNA) by acting on the CNS. In rabbits anesthetized with alpha-chloralose, we examined changes in arterial pressure and renal SNA in response to graded electrical stimulation (1.7, 3.3, 5.0 Hz) of aortic depressor nerves during the i.v. infusion of saline or alpha-human atrial natriuretic peptide (alpha-hANP) (0.1, 1.0 microgram/kg/min) or after the i.c.v. injections of saline or alpha-hANP (3, 10 micrograms). Sinoaortic denervation and bilateral vagotomy were done before examination in all rabbits to eliminate the influence of the known effects of ANP on arterial and cardiac receptors. I.v. alpha-hANP decreased arterial pressure but did not alter renal SNA. I.c.v. alpha-hANP did not change arterial pressure or renal SNA. Arterial pressure and renal nerve responses to graded electrical stimulation of aortic depressor nerves were not altered by i.v. or i.c.v. alpha-hANP. These results suggest that alpha-hANP does not modulate control of renal SNA by acting on the CNS.
S Suzuki; A Takeshita; T Imaizumi; Y Hirooka; M Yoshida; M Nakamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  485     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-23     Completed Date:  1989-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Adrenergic Fibers / drug effects,  physiology*
Atrial Natriuretic Factor / pharmacology*
Blood Pressure / drug effects
Brain / drug effects,  physiology*
Injections, Intraventricular
Pressoreceptors / drug effects,  physiology*
Sinoatrial Node / drug effects,  physiology*
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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