| Evidence for adult lung growth in humans. | |
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MedLine Citation:
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PMID: 22808959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of a lung adenocarcinoma. As expected, there was an abrupt decrease in her vital capacity, but unexpectedly, it increased during the subsequent 15 years. Serial computed tomographic (CT) scans showed progressive enlargement of the remaining left lung and an increase in tissue density. Magnetic resonance imaging (MRI) with the use of hyperpolarized helium-3 gas showed overall acinar-airway dimensions that were consistent with an increase in the alveolar number rather than the enlargement of existing alveoli, but the alveoli in the growing lung were shallower than in normal lungs. This study provides evidence that new lung growth can occur in an adult human. |
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Authors:
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James P Butler; Stephen H Loring; Samuel Patz; Akira Tsuda; Dmitriy A Yablonskiy; Steven J Mentzer |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The New England journal of medicine Volume: 367 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-19 Completed Date: 2012-07-26 Revised Date: 2013-04-05 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 244-7 Citation Subset: AIM; IM |
Affiliation:
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Division of Sleep Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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surgery Adult Female Humans Imaging, Three-Dimensional Lung / pathology, physiology*, radiography Lung Neoplasms / surgery Magnetic Resonance Imaging Pneumonectomy* Regeneration* Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL052586/HL/NHLBI NIH HHS; R01 HL054885/HL/NHLBI NIH HHS; R01 HL054885/HL/NHLBI NIH HHS; R01 HL07003/HL/NHLBI NIH HHS; R01 HL070037/HL/NHLBI NIH HHS; R01 HL094567/HL/NHLBI NIH HHS; R01 HL094567/HL/NHLBI NIH HHS; R01 HL096471/HL/NHLBI NIH HHS; R01 HL096471/HL/NHLBI NIH HHS; R01 HL52586/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 2012 Oct 18;367(16):1567; author reply 1567
[PMID:
23075189
]
N Engl J Med. 2012 Oct 18;367(16):1566-7; author reply 1567 [PMID: 23075188 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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