Document Detail


Evidence for adult lung growth in humans.
MedLine Citation:
PMID:  22808959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of a lung adenocarcinoma. As expected, there was an abrupt decrease in her vital capacity, but unexpectedly, it increased during the subsequent 15 years. Serial computed tomographic (CT) scans showed progressive enlargement of the remaining left lung and an increase in tissue density. Magnetic resonance imaging (MRI) with the use of hyperpolarized helium-3 gas showed overall acinar-airway dimensions that were consistent with an increase in the alveolar number rather than the enlargement of existing alveoli, but the alveoli in the growing lung were shallower than in normal lungs. This study provides evidence that new lung growth can occur in an adult human.
Authors:
James P Butler; Stephen H Loring; Samuel Patz; Akira Tsuda; Dmitriy A Yablonskiy; Steven J Mentzer
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The New England journal of medicine     Volume:  367     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-19     Completed Date:  2012-07-26     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  AIM; IM    
Affiliation:
Division of Sleep Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / surgery
Adult
Female
Humans
Imaging, Three-Dimensional
Lung / pathology,  physiology*,  radiography
Lung Neoplasms / surgery
Magnetic Resonance Imaging
Pneumonectomy*
Regeneration*
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
R01 HL052586/HL/NHLBI NIH HHS; R01 HL054885/HL/NHLBI NIH HHS; R01 HL054885/HL/NHLBI NIH HHS; R01 HL07003/HL/NHLBI NIH HHS; R01 HL070037/HL/NHLBI NIH HHS; R01 HL094567/HL/NHLBI NIH HHS; R01 HL094567/HL/NHLBI NIH HHS; R01 HL096471/HL/NHLBI NIH HHS; R01 HL096471/HL/NHLBI NIH HHS; R01 HL52586/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
N Engl J Med. 2012 Oct 18;367(16):1566-7; author reply 1567   [PMID:  23075188 ]
N Engl J Med. 2012 Oct 18;367(16):1567; author reply 1567   [PMID:  23075189 ]

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