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MedLine Citation:
PMID:  23025610     Owner:  NLM     Status:  Publisher    
To understand how organisms adapt to novel habitats, which involves both demographic and selective events, we require knowledge of the evolutionary history of populations and also selected alleles. There are still few cases in which the precise mutations (and hence, defined alleles) that contribute to adaptive change have been identified in nature; one exception is the genetic basis of camouflaging pigmentation of oldfield mice (Peromyscus polionotus) that have colonized the sandy dunes of Florida's Gulf Coast. To quantify the genomic impact of colonization as well as the signature of selection, we resequenced 5000 1.5-kb noncoding loci as well as a 160-kb genomic region surrounding the melanocortin-1 receptor (Mc1r), a gene that contributes to pigmentation differences, in beach and mainland populations. Using a genome-wide phylogenetic approach, we recovered a single monophyletic group comprised of beach mice, consistent with a single colonization event of the Gulf Coast. We also found evidence of a severe founder event, estimated to have occurred less than 3000 years ago. In this demographic context, we show that all beach subspecies share a single derived light Mc1r allele, which was likely selected from standing genetic variation that originated in the mainland. Surprisingly, we were unable to identify a clear signature of selection in the Mc1r region, despite independent evidence that this locus contributes to adaptive coloration. Nonetheless, these data allow us to reconstruct and compare the evolutionary history of populations and alleles to better understand how adaptive evolution, following the colonization of a novel habitat, proceeds in nature.
Vera S Domingues; Yu-Ping Poh; Brant K Peterson; Pleuni S Pennings; Jeffrey D Jensen; Hopi E Hoekstra
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-4
Journal Detail:
Title:  Evolution; international journal of organic evolution     Volume:  66     ISSN:  1558-5646     ISO Abbreviation:  Evolution     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373224     Medline TA:  Evolution     Country:  -    
Other Details:
Languages:  ENG     Pagination:  3209-3223     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s). Evolution© 2012 The Society for the Study of Evolution.
Department of Organismic & Evolutionary Biology, Harvard University, Cambridge 02138, Massachusetts Department of Molecular & Cellular Biology, Harvard University, Cambridge 02138, Massachusetts Museum of Comparative Zoology, Harvard University, Cambridge 02138, Massachusetts E-mail: Program in Bioinformatics & Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
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