Document Detail


Evidence for activation of the sympathetic nervous system by recombinant human interleukin-1 beta in humans.
MedLine Citation:
PMID:  8318499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Administration of interleukin-1 beta (IL-1 beta) to humans initiates a cascade of metabolic, hematologic, and cardiovascular events. To investigate the role of the sympathetic nervous system in the early cardiovascular response to IL-1 beta in humans, we recorded the heart rate, blood pressure, and changes in hand vein compliance in five patients with malignant melanoma treated with a 30-min infusion of 10,000-20,000 U/kg of human recombinant IL-1 beta. All patients developed fever, chills, and marked hemodynamic changes. During or shortly after the infusion, a dramatic decrease in hand vein compliance occurred (vasoconstriction). At the time of maximum venoconstriction (35 min after the start of the IL-1 beta infusion), the mean heart rate and systolic blood pressure were significantly increased by 30 mm Hg and 31 beats/min, respectively. Venoconstriction always preceded the onset of chills by several minutes (mean of 7 min), was closely correlated with the heart rate, and could be reversed by local administration of the alpha-antagonist phentolamine, indicating involvement of catecholamines. Our study shows that cardiovascular responses that occur early after IL-1 beta administration in humans are most likely the result of adrenergic stimulation possibly through its effect on the central nervous system.
Authors:
W E Haefeli; M J Bargetzi; H F Starnes; T F Blaschke; B B Hoffman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy     Volume:  13     ISSN:  1067-5582     ISO Abbreviation:  J Immunother Emphasis Tumor Immunol     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-08-03     Completed Date:  1993-08-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9418950     Medline TA:  J Immunother Emphasis Tumor Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  136-40     Citation Subset:  IM    
Affiliation:
Department of Medicine, Stanford University School of Medicine, California.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure / drug effects
Female
Heart Rate / drug effects
Humans
Immunotherapy
Infusions, Intravenous
Interleukin-1 / pharmacology*,  therapeutic use
Male
Melanoma / physiopathology,  therapy
Middle Aged
Recombinant Proteins / therapeutic use
Sympathetic Nervous System / physiology*
Vasoconstriction / drug effects
Grant Support
ID/Acronym/Agency:
AG-05627/AG/NIA NIH HHS; RR00070/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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