Document Detail

Evidence for activation of the alternate complement pathway in patients with juvenile rheumatoid arthritis.
MedLine Citation:
PMID:  10725071     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Complement activation has been shown to occur in patients with juvenile rheumatoid arthritis (JRA). Since the two pathways of complement are activated by different stimuli (the alternate pathway by microbial products and IgA, and the classical pathway by immune complexes), we decided to study the relative contribution of the two pathways of complement activation in patients with JRA. METHODS: In 56 patients with JRA, plasma levels of C3 and C4 were measured by turbidimetric assays, and those of C4d, factor Bb and sC5-9 complex by solid-phase enzyme immunoassays. Levels beyond the mean +/- 2 S.D. of normal were considered abnormal. RESULTS: Plasma C3 and C4 levels were decreased in one patient each. The C4d values were increased in 17 patients, whereas levels of factor Bb were elevated in 42 patients and levels of sC5-9 complex were elevated in 51 patients. The values of factor Bb and sC5-9 had a linear correlation (r = 0.75), but there was no significant correlation between C4d and sC5-9 levels (r = 0.36). CONCLUSION: Complement activation in JRA is initiated predominantly by the alternate pathway and culminates in the formation of terminal membrane attack complex.
A Aggarwal; A Bhardwaj; S Alam; R Misra
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  39     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-19     Completed Date:  2000-04-19     Revised Date:  2007-09-06    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  AIM; IM    
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India.
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MeSH Terms
Antigen-Antibody Complex / immunology
Arthritis, Juvenile Rheumatoid / blood,  immunology*
Blood Sedimentation
C-Reactive Protein / analysis
Child, Preschool
Complement Activation
Complement C3 / immunology
Complement C4 / immunology
Complement C4b*
Complement C5 / immunology
Complement Pathway, Alternative / immunology*
Immunoenzyme Techniques
Peptide Fragments / immunology
Platelet-Derived Growth Factor / immunology
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Complement C3; 0/Complement C4; 0/Complement C5; 0/Peptide Fragments; 0/Platelet-Derived Growth Factor; 0/platelet-derived growth factor BB; 80295-50-7/Complement C4b; 80295-52-9/complement C4d; 9007-41-4/C-Reactive Protein

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