Document Detail

Evidence for abrogation of oncogene-induced radioresistance of mammary cancer cells by hexadecylphosphocholine in vitro.
MedLine Citation:
PMID:  8280489     Owner:  NLM     Status:  MEDLINE    
Hexadecylphosphocholine (HePC), an experimental and clinical antitumour agent of the alkyllysophospholipid group, was tested for its radiosensitising effect on a panel of nine human mammary cancer cell lines in vitro. Growth inhibition by ionising radiation and recovery from it were not influenced by pretreatment with HePC in most cases, except for two cell lines expressing an activated ras oncogene. In the latter we found an enhanced radioresistance that was abolished by pretreatment with HePC. Our results suggest that HePC may act as a radiosensitiser for cells carrying an activated ras oncogene.
E A Bruyneel; G A Storme; D C Schallier; D L Van den Berge; P Hilgard; M M Mareel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  29A     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1993  
Date Detail:
Created Date:  1994-02-16     Completed Date:  1994-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1958-63     Citation Subset:  IM    
Department of Radiotherapy, University Hospital Ghent, Belgium.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Breast Neoplasms / genetics*
Cell Survival / drug effects
Gene Expression Regulation, Neoplastic
Genes, ras*
Phosphorylcholine / analogs & derivatives*,  pharmacology
Radiation Tolerance / drug effects*
Radiation-Sensitizing Agents / pharmacology*
Time Factors
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
0/Antineoplastic Agents; 0/Radiation-Sensitizing Agents; 107-73-3/Phosphorylcholine; 58066-85-6/miltefosine
Erratum In:
Eur J Cancer 1994;30A(4):571

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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