Document Detail

Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.
MedLine Citation:
PMID:  16342298     Owner:  NLM     Status:  MEDLINE    
Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) show genotypic features of germinal centre-derived B-cells in most cases. Nevertheless, these cells typically lack expression of B-cell antigens. Previous studies have suggested that plasma cell differentiation may occur in HRS cells and that this may account for the down-regulation of B-cell antigens. However, these results are controversial. We have addressed this question using immunohistochemistry and a panel of antibodies directed against antigens which are differentially expressed during terminal B-cell differentiation. Pax-5, a transcription factor required for B-lineage commitment, and IRF4/Mum1, which is physiologically expressed in germinal centre cells and plasma cells, were consistently detectable in HRS cells. Bcl-6, a transcription factor expressed in germinal centre B-cells, was present in HRS cells of approximately 25% of cHL cases. Expression of the B-lymphocyte-induced maturation protein-1 (Blimp-1), a key regulator of plasma cell differentiation, was observed in HRS cells of 23% of cHL cases. In these cases, Blimp-1 expression was restricted to a small proportion of HRS cells. HRS cells were consistently negative for the plasma cell marker CD138. These results suggest that plasma cell differentiation may be initiated in a small subset of HRS cells but remains abortive. Thus, terminal differentiation is unlikely to explain the lack of B-cell antigen expression in HRS cells.
Maike Buettner; Axel Greiner; Athanasia Avramidou; Hans-Martin Jäck; Gerald Niedobitek
Related Documents :
16674678 - Differentiation of human ameloblast-lineage cells in vitro.
1655528 - Cellular hsp90 (hsp86) mrna level and in vitro differentiation of mouse embryonal carci...
7828548 - Regulation of deoxyribonucleic acid synthesis in proliferating and differentiating trop...
23876278 - Host blood meal-dependent growth ensures transovarial transmission and transstadial pas...
11000888 - Immunohistochemical study of microglial and astroglial cells during postnatal developme...
21078298 - Nano-mechanical properties of living cells expressing constitutively active rhoa effect...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Hematological oncology     Volume:  23     ISSN:  0278-0232     ISO Abbreviation:  -     Publication Date:    2005 Sep-Dec
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8307268     Medline TA:  Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Copyright Information:
2005 John Wiley & Sons, Ltd.
Institute for Pathology, Department of Internal Medicine III, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University, Erlangen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Transformation, Neoplastic / metabolism*,  pathology
Gene Expression Regulation, Leukemic*
Hodgkin Disease / metabolism*,  pathology
Membrane Glycoproteins / biosynthesis
Neoplasm Proteins / biosynthesis*
Plasma Cells / metabolism*,  pathology
Proteoglycans / biosynthesis
Reed-Sternberg Cells / metabolism*,  pathology
Transcription Factors / biosynthesis*
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Neoplasm Proteins; 0/Proteoglycans; 0/SDC1 protein, human; 0/Syndecan-1; 0/Syndecans; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ionizing radiation and leukaemia: more questions than answers.
Next Document:  Pharmacoepidemiology of antihypertensive drugs in primary care setting of Bahrain between 1998 and 2...