Document Detail


Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.
MedLine Citation:
PMID:  16342298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) show genotypic features of germinal centre-derived B-cells in most cases. Nevertheless, these cells typically lack expression of B-cell antigens. Previous studies have suggested that plasma cell differentiation may occur in HRS cells and that this may account for the down-regulation of B-cell antigens. However, these results are controversial. We have addressed this question using immunohistochemistry and a panel of antibodies directed against antigens which are differentially expressed during terminal B-cell differentiation. Pax-5, a transcription factor required for B-lineage commitment, and IRF4/Mum1, which is physiologically expressed in germinal centre cells and plasma cells, were consistently detectable in HRS cells. Bcl-6, a transcription factor expressed in germinal centre B-cells, was present in HRS cells of approximately 25% of cHL cases. Expression of the B-lymphocyte-induced maturation protein-1 (Blimp-1), a key regulator of plasma cell differentiation, was observed in HRS cells of 23% of cHL cases. In these cases, Blimp-1 expression was restricted to a small proportion of HRS cells. HRS cells were consistently negative for the plasma cell marker CD138. These results suggest that plasma cell differentiation may be initiated in a small subset of HRS cells but remains abortive. Thus, terminal differentiation is unlikely to explain the lack of B-cell antigen expression in HRS cells.
Authors:
Maike Buettner; Axel Greiner; Athanasia Avramidou; Hans-Martin Jäck; Gerald Niedobitek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Hematological oncology     Volume:  23     ISSN:  0278-0232     ISO Abbreviation:  -     Publication Date:    2005 Sep-Dec
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8307268     Medline TA:  Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Copyright Information:
2005 John Wiley & Sons, Ltd.
Affiliation:
Institute for Pathology, Department of Internal Medicine III, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University, Erlangen, Germany. maike.buettner@patho.imed.uni-erlangen.de
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MeSH Terms
Descriptor/Qualifier:
Cell Transformation, Neoplastic / metabolism*,  pathology
Gene Expression Regulation, Leukemic*
Hodgkin Disease / metabolism*,  pathology
Humans
Immunohistochemistry
Membrane Glycoproteins / biosynthesis
Neoplasm Proteins / biosynthesis*
Plasma Cells / metabolism*,  pathology
Proteoglycans / biosynthesis
Reed-Sternberg Cells / metabolism*,  pathology
Syndecan-1
Syndecans
Transcription Factors / biosynthesis*
Chemical
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Neoplasm Proteins; 0/Proteoglycans; 0/SDC1 protein, human; 0/Syndecan-1; 0/Syndecans; 0/Transcription Factors

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