Document Detail


Evidence for sympathetic origins of hypertension in juvenile offspring of obese rats.
MedLine Citation:
PMID:  19901159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal obesity in rodents is associated with increased adiposity, impaired glucose tolerance, and hypertension in adult offspring. In this study we investigated the influence of maternal obesity in the rat on blood pressure and blood pressure regulatory pathways in juvenile and adult offspring. Obesity was induced before pregnancy in female Sprague-Dawley rats by feeding a highly palatable energy-dense diet. In juvenile animals (30 days of age), before the onset of obesity and hyperleptinemia, basal nighttime mean arterial pressure was significantly raised in the offspring of obese dams (OffOb) relative to offspring of controls (OffCon; mean arterial pressure, males: OffOb, 121.8+/-0.6 mm Hg versus OffCon, 115.0+/-0.5 mm Hg, n=6, P<0.01; females: OffOb, 125.4+/-0.4 mm Hg versus OffCon, 114.4+/-0.5 mm Hg, n=6, P<0.001), as was the mean arterial pressure response to restraint stress (P<0.01). The pressor response to a leptin challenge was enhanced in OffOb rats (Deltamean arterial pressure: OffOb, 9.7+/-0.8 mm Hg versus OffCon, 5.3+/-1.3 mm Hg; n=8; P<0.05). Renal tissue norepinephrine content (P<0.001) and renin expression (P<0.05) were markedly raised. Analysis of heart rate variability revealed an increased low:high frequency ratio in OffOb versus OffCon rats (P<0.05). At 90 days, hypertension in OffOb rats persisted and was abolished by alpha1- and beta-adrenergic blockade, and cardiovascular responses to phenylephrine or sodium nitroprusside indicated altered baroreceptor function. The exaggerated pressor response to leptin in OffOb rats was maintained. Hypertension in the offspring of obese rats may arise from persistent sympathoexcitatory hyperresponsiveness acquired in early stages of development.
Authors:
Anne-Maj Samuelsson; Abigail Morris; Natalia Igosheva; Shona L Kirk; Joaquim M C Pombo; Clive W Coen; Lucilla Poston; Paul D Taylor
Related Documents :
9825209 - Blood pressure in children exposed prenatally to cocaine.
15586739 - Prevalence of sustained hypertension and obesity in urban and rural school going childr...
11911449 - Length of marriage and its effect on spousal concordance in kuwait.
10423099 - Weight reduction and obesity.
8554729 - Effect of weight loss on blood pressure and insulin resistance in normotensive and hype...
2225369 - Blood pressure level, trend, and variability in dunedin children. an 8-year study of a ...
23196259 - Effects of recruitment maneuver and positive end-expiratory pressure on respiratory mec...
8577209 - Staurosporine inhibits the effects of leukotrienes c4 and d4 in isolated guinea pig hea...
2809809 - Myogenic mechanisms in the control of systemic resistance and transcapillary fluid exch...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-09
Journal Detail:
Title:  Hypertension     Volume:  55     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  IM    
Affiliation:
Division of Reproduction and Endocrinology, King's College London, 10th Floor North Wing, St. Thomas' Hospital, London SE1 7EH, UK. anne-maj.samuelsson@kcl.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Animals, Newborn
Baroreflex
Blood Pressure
Body Weight
Dietary Fats / administration & dosage
Female
Hypertension / embryology,  etiology,  physiopathology*
Kidney / metabolism
Male
Norepinephrine / metabolism
Obesity / etiology,  physiopathology*
Peptidyl-Dipeptidase A / blood
Pregnancy
Pregnancy Complications / etiology,  physiopathology*
Prenatal Exposure Delayed Effects / etiology,  physiopathology
RNA, Messenger / genetics,  metabolism
Rats
Rats, Sprague-Dawley
Renin / genetics
Sex Factors
Sympathetic Nervous System / physiopathology*
Time Factors
Weaning
Grant Support
ID/Acronym/Agency:
BBD5231861//Biotechnology and Biological Sciences Research Council; PG/06/067//British Heart Foundation
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/RNA, Messenger; 51-41-2/Norepinephrine; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.23.15/Renin
Comments/Corrections
Comment In:
Hypertension. 2010 Jan;55(1):21-2   [PMID:  19901157 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protei...
Next Document:  Induction of Mitogen-Activated Protein Kinases Is Proportional to the Amount of Pressure Overload.