Document Detail

Evidence for sympathetic origins of hypertension in juvenile offspring of obese rats.
MedLine Citation:
PMID:  19901159     Owner:  NLM     Status:  MEDLINE    
Maternal obesity in rodents is associated with increased adiposity, impaired glucose tolerance, and hypertension in adult offspring. In this study we investigated the influence of maternal obesity in the rat on blood pressure and blood pressure regulatory pathways in juvenile and adult offspring. Obesity was induced before pregnancy in female Sprague-Dawley rats by feeding a highly palatable energy-dense diet. In juvenile animals (30 days of age), before the onset of obesity and hyperleptinemia, basal nighttime mean arterial pressure was significantly raised in the offspring of obese dams (OffOb) relative to offspring of controls (OffCon; mean arterial pressure, males: OffOb, 121.8+/-0.6 mm Hg versus OffCon, 115.0+/-0.5 mm Hg, n=6, P<0.01; females: OffOb, 125.4+/-0.4 mm Hg versus OffCon, 114.4+/-0.5 mm Hg, n=6, P<0.001), as was the mean arterial pressure response to restraint stress (P<0.01). The pressor response to a leptin challenge was enhanced in OffOb rats (Deltamean arterial pressure: OffOb, 9.7+/-0.8 mm Hg versus OffCon, 5.3+/-1.3 mm Hg; n=8; P<0.05). Renal tissue norepinephrine content (P<0.001) and renin expression (P<0.05) were markedly raised. Analysis of heart rate variability revealed an increased low:high frequency ratio in OffOb versus OffCon rats (P<0.05). At 90 days, hypertension in OffOb rats persisted and was abolished by alpha1- and beta-adrenergic blockade, and cardiovascular responses to phenylephrine or sodium nitroprusside indicated altered baroreceptor function. The exaggerated pressor response to leptin in OffOb rats was maintained. Hypertension in the offspring of obese rats may arise from persistent sympathoexcitatory hyperresponsiveness acquired in early stages of development.
Anne-Maj Samuelsson; Abigail Morris; Natalia Igosheva; Shona L Kirk; Joaquim M C Pombo; Clive W Coen; Lucilla Poston; Paul D Taylor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-09
Journal Detail:
Title:  Hypertension     Volume:  55     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  IM    
Division of Reproduction and Endocrinology, King's College London, 10th Floor North Wing, St. Thomas' Hospital, London SE1 7EH, UK.
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MeSH Terms
Analysis of Variance
Animals, Newborn
Blood Pressure
Body Weight
Dietary Fats / administration & dosage
Hypertension / embryology,  etiology,  physiopathology*
Kidney / metabolism
Norepinephrine / metabolism
Obesity / etiology,  physiopathology*
Peptidyl-Dipeptidase A / blood
Pregnancy Complications / etiology,  physiopathology*
Prenatal Exposure Delayed Effects / etiology,  physiopathology
RNA, Messenger / genetics,  metabolism
Rats, Sprague-Dawley
Renin / genetics
Sex Factors
Sympathetic Nervous System / physiopathology*
Time Factors
Grant Support
BBD5231861//Biotechnology and Biological Sciences Research Council; PG/06/067//British Heart Foundation
Reg. No./Substance:
0/Dietary Fats; 0/RNA, Messenger; 51-41-2/Norepinephrine; EC A; EC
Comment In:
Hypertension. 2010 Jan;55(1):21-2   [PMID:  19901157 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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