| Evidence Supporting the use of Probiotics for the Prevention and Treatment of Chemotherapy-Induced Intestinal Mucositis. | |
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MedLine Citation:
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PMID: 21390944 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Although chemotherapy remains the current best practice for the treatment of neoplasia, the severity of its associated side-effects continues to impact detrimentally on the quality of life. Mucositis can affect both the oral cavity and intestine, and represents one of the most common side-effects of chemotherapy. It is characterized by ulceration, inflammation, diarrhoea, and intense abdominal pain. Despite extensive research there remains no definitive therapy for mucositis. This may be due to the multiple factors which contribute to its pathogenesis, including up-regulation of pro-inflammatory cytokines, increased apoptosis of epithelial cells, alteration of the gastrointestinal microbiota, and damage to the epithelium. Although employed increasingly in other gastrointestinal disorders, probiotics are yet to be comprehensively investigated in the treatment or prevention of chemotherapy-induced mucositis. Probiotic-based therapies have been shown to exert beneficial effects, including modulation of the microbiota and inhibition of pro-inflammatory cytokines. This review outlines the current evidence supporting the use of probiotics in intestinal mucositis, and suggests further research directions for the future. |
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Authors:
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Luca D Prisciandaro; Mark S Geier; Ross N Butler; Adrian G Cummins; Gordon S Howarth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Critical reviews in food science and nutrition Volume: 51 ISSN: 1549-7852 ISO Abbreviation: Crit Rev Food Sci Nutr Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8914818 Medline TA: Crit Rev Food Sci Nutr Country: England |
Other Details:
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Languages: eng Pagination: 239-47 Citation Subset: IM |
Affiliation:
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Discipline of Agricultural and Animal Science, School of Agriculture, Food and Wine, University of Adelaide, South Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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