| Evidence of shared genetic effects between pre- and postobesity epidemic BMI levels. | |
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MedLine Citation:
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PMID: 19876002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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United States has experienced a widespread obesity epidemic. However, it is unclear whether the obesogenic environment has uncovered genes previously unimportant in adiposity or whether genes influencing obesity are the same before and after the obesity epidemic. The objective of this study was to test whether BMI pre- and postobesity epidemic would be controlled by shared genetic effects. A 25-30-year follow-up of parents and children who participated in the National Institutes of Health-National Heart, Lung, and Blood Institute Lipid Research Clinics (LRC) Princeton School Study, 1973-1976, were followed up in 1999-2004 in the Princeton Follow-up Study (PFS). Heritability of BMI and genetic correlations between pre-epidemic BMI and BMI z-scores in adolescents and postobesity epidemic BMI were calculated. Even though they had similar ages, offspring had higher BMI in PFS than their parents in LRC (28.5 +/- 6.6 vs. 26.1 +/- 4.4, P < 0.0001). BMI measurements in offspring were strongly heritable (BMI(LRC): h(2) = 0.78 +/- 0.17; BMI z-score(LRC): h(2) = 0.61 +/- 0.16; BMI(PFS): h(2) = 0.64 +/- 0.16, all P < or = 0.0001). Further, the change of BMI exhibited a high heritability (h(2) = 0.51 +/- 0.18, P = 0.003). Bivariate analysis of BMI in LRC and PFS showed significant genetic correlation (0.70 +/- 0.16, P = 0.005), whereas the environmental correlation was not significant (0.36 +/- 0.17). Although the obesogenic environment may have changed between the 1970s and 2000s, many of the same genes are likely to be involved in establishing genetic susceptibility to obesity. Furthermore, shared genetic effects survive the period of the transition from adolescence to adulthood. |
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Authors:
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Lisa J Martin; Jessica G Woo; John A Morrison |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-29 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1378-82 Citation Subset: IM |
Affiliation:
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Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Body Mass Index* Child Cohort Studies Disease Outbreaks Family Health* Female Follow-Up Studies Genetic Predisposition to Disease / epidemiology Humans Male Models, Genetic Obesity / epidemiology*, genetics* Parents* Prevalence Siblings Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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GM28356/GM/NIGMS NIH HHS; N01-HV-2-2914-L/HV/NHLBI NIH HHS; R01 HL1-62394/HL/NHLBI NIH HHS; RR03635/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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