Document Detail

Evidence of persistent cognitive impairment after resolution of overt hepatic encephalopathy.
MedLine Citation:
PMID:  20951832     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: The Inhibitory Control Test has been proposed as a tool to detect the persistence of cognitive defects after the resolution of overt hepatic encephalopathy (OHE). We tested learning abilities of cirrhotic patients using the Psychometric Hepatic Encephalopathy Score (PHES).
METHODS: One hundred six cirrhotic patients who agreed to be examined twice within 3 days were studied using the PHES. Twenty-seven patients had previous OHE; of the remaining 79 patients, 34 were affected by minimal HE and 45 were normal.
RESULTS: Among patients without previous OHE, PHESs significantly improved at the second examination; this learning effect was present in the patients with or without minimal HE. To the contrary, learning ability was lost in patients with previous OHE. Even among the 8 patients with history of HE and normal PHESs in the first examination, repeated testing showed a lack of learning capacity.
CONCLUSIONS: HE is not a fully reversible condition. Residual cognitive impairments should be evaluated by specific tests, based on patients' learning capacities.
Oliviero Riggio; Lorenzo Ridola; Chiara Pasquale; Silvia Nardelli; Ilaria Pentassuglio; Federica Moscucci; Manuela Merli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-15
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  9     ISSN:  1542-7714     ISO Abbreviation:  Clin. Gastroenterol. Hepatol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  2011-05-31     Revised Date:  2011-08-11    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
Department of Clinical Medicine, Center for Diagnosis and Treatment of Portal Hypertension, Sapienza University of Rome, Rome, Italy.
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MeSH Terms
Cognition Disorders / diagnosis,  etiology*
Hepatic Encephalopathy / complications*,  therapy
Learning Disorders / diagnosis,  etiology*
Middle Aged
Neuropsychological Tests*
Comment In:
Clin Gastroenterol Hepatol. 2011 Jul;9(7):624; author reply 624-5   [PMID:  21334456 ]

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