| Evidence of a parathyroid hormone-independent chronic effect of estrogen on renal phosphate handling and sodium-dependent phosphate cotransporter type IIa expression. | |
| | |
MedLine Citation:
|
PMID: 20119884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of estrogen on phosphate metabolism are not well understood. To better define the chronic effects of estrogen on phosphate balance and on renal phosphate handling, the following groups were examined: A. young male and female rats, age- and weight-matched (age 8-10 weeks, 1 (st) study), and B. ovariectomized female rats (OVX), 22 weeks old, ovariectomized aged-matched rats receiving estrogen replacement (15 micromol x 3/week) for 14 weeks (OVX+E), control female rats (intact ovaries), and male rats, both age matched to OVX and OVX+E (2 (nd) Study). In younger females (1 (st) study), plasma phosphate was lower, whereas the urinary excretion of phosphate was higher than in males. In adult intact females and in OVX+E urinary excretion of phosphate was higher than in males and OVX (2 (nd) Study). In these rats, a significant correlation between plasma phosphate and estrogen level was found. Sodium-dependent phosphate cotransporter (NaPiIIa) mRNA expression and protein abundance were higher in the renal cortex of younger male rats than in age- and weight-matched females. In adult rats, NaPiIIa mRNA and protein abundance were higher in OVX than in OVX+E, and in mature males as compared with age-matched females. These differences were not related to the parathyroid hormone (PTH) levels. Chronic estrogen administration was also associated with increased plasma calcium level and urinary calcium excretion. These results suggest that chronic estrogen treatment is associated with an inhibitory, PTH-independent effect on the expression of NaPiIIa in the kidney, leading to sex-related differences in phosphate balance. |
| | |
Authors:
|
L Guttmann-Rubinstein; D Lichtstein; A Ilani; A Gal-Moscovici; P Scherzer; D Rubinger |
Related Documents
:
|
9753084 - Nitric oxide production is increased in the paraventricular nucleus of the hypothalamus... 12128064 - Changes of major carotenoids in gonads of sea urchins (strongylocentrotus intermedius a... 21551784 - Structural and functional regeneration in hairy and glabrous skin after fibrin sealing ... 7713334 - Two-year inhalation exposure of female and male b6c3f1 mice and f344 rats to chlorine g... 16673204 - Morphological and histopathological changes in tongues of experimentally developed acro... 5145894 - The effects of the stress caused by experimental procedures on alanine, aspartate, glut... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-01-29 |
Journal Detail:
|
Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et m?tabolisme Volume: 42 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-31 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 230-6 Citation Subset: IM |
Copyright Information:
|
Georg Thieme Verlag KG Stuttgart New York. |
Affiliation:
|
Department of Medicine, Hadassah University Medical Center, The Hebrew University Hadassah Medical School, Jerusalem, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
drug effects,
metabolism Animals Estrogens / administration & dosage, blood, pharmacology* Female Gene Expression Regulation / drug effects Kidney / drug effects*, metabolism* Male Parathyroid Hormone / metabolism Phosphates / metabolism* Protein Subunits / genetics, metabolism RNA, Messenger / genetics, metabolism Rats Rats, Wistar Sodium-Phosphate Cotransporter Proteins, Type IIa / genetics, metabolism* Sodium-Potassium-Exchanging ATPase / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Estrogens; 0/Parathyroid Hormone; 0/Phosphates; 0/Protein Subunits; 0/RNA, Messenger; 0/Sodium-Phosphate Cotransporter Proteins, Type IIa; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mineralocorticoid Antagonists Treatment Versus Surgery in Primary Aldosteronism.
Next Document: Is Primary Aldosteronism Associated with Diabetes Mellitus? Results of the German Conn's Registry.