Document Detail


Evidence of oral translocation of anionic G6.5 dendrimers in mice.
MedLine Citation:
PMID:  23286733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of carrier systems to improve oral bioavailability and target drugs to specific sites continues to be an unmet need. The goal of this study was to evaluate the potential of anionic generation (G) 6.5 poly(amido amine) (PAMAM) dendrimers in oral drug delivery by assessing their in vivo oral translocation. G6.5-COOH dendrimers were characterized for their physiochemical characteristics and acute oral toxicity was assessed in CD-1 mice. The dendrimers were labeled with (125)I and their stability evaluated. Oral bioavailability was assessed in the same mouse model. Investigation of the radioactivity profile in plasma revealed presence of both large and small molecular weight compounds. Detailed area under the curve analysis suggests an effective 9.4% bioavailability of radiolabeled marker associated with G6.5-COOH. Results reported here suggest the potential of dendrimers in permeating gastrointestinal barriers in vivo.
Authors:
Giridhar Thiagarajan; Shraddha Sadekar; Khaled Greish; Abhijit Ray; Hamidreza Ghandehari
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-25
Journal Detail:
Title:  Molecular pharmaceutics     Volume:  10     ISSN:  1543-8392     ISO Abbreviation:  Mol. Pharm.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-04     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101197791     Medline TA:  Mol Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  988-98     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Area Under Curve
Dendrimers / administration & dosage*,  chemistry,  pharmacokinetics*
Drug Carriers / administration & dosage,  chemistry,  pharmacokinetics
Female
Intestines / chemistry
Mice
Stomach / chemistry
Grant Support
ID/Acronym/Agency:
R01 DE019050/DE/NIDCR NIH HHS; R01 EB007470/EB/NIBIB NIH HHS; R01DE019050/DE/NIDCR NIH HHS; R01EB007470/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Dendrimers; 0/Drug Carriers; 0/PAMAM Starburst
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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