| Evidence for N-methyl-D-aspartate receptor mediation of cocaine induced corticosterone release and cocaine conditioned stimulant effects. | |
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MedLine Citation:
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PMID: 7654307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of the N-methyl-D-aspartate (NMDA) receptors in cocaine conditioning and sensitization of locomotor activity was studied in four groups of Sprague-Dawley rats. A sub-motoric dose of the NMDA antagonist MK-801 (0.1 mg/kg, i.p.) was employed using a novel dual-compartment Pavlovian drug conditioning paradigm. The animals were placed sequentially in two different test environments in which locomotor activity was monitored. In the first compartment, the animals always received a non-drug test for 20 min. Upon completion of this test, the animals received either saline, cocaine (10 mg/kg i.p.), MK-801 or MK-801 plus cocaine depending on group assignment and were then placed immediately into the second compartment and again tested for 20 min. A total of six non-drug and six drug tests were conducted every other day over a 12-day period. Across all drug/saline treatment and post-treatment tests for conditioning, there were no statistical differences in locomotor activity among the saline and drug treatment groups in the non-drug test environment. In the drug/saline associated environment, however, cocaine had a reliable stimulant effect on locomotion when administered alone or in combination with MK-801. Following a 1-day and again after 21-days of withdrawal, all animals were administered a non-drug test for conditioning in which no injections were administered. On both tests, all groups had equivalent activity levels in the non-drug environment. In the drug/saline environment, only the cocaine group of the three drug treatment groups exhibited conditioned hyperlocomotion. Importantly, MK-801 blocked conditioned hyperlocomotion in the combined cocaine+MK-801 group. MK-801 did not alter serum or brain cocaine concentration or the cocaine effects on dopamine metabolism in limbic brain tissue. The co-administration of MK-801 with cocaine, however, blocked the corticosterone release effect of cocaine. Thus, the NMDA receptor site appears critical for cocaine induced conditioning and for corticosterone release. |
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Authors:
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E N Damianopoulos; R J Carey |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Behavioural brain research Volume: 68 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-10-05 Completed Date: 1995-10-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 219-28 Citation Subset: IM |
Affiliation:
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SUNY Health Science Center, Syracuse, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arousal / drug effects* Association Learning / drug effects Brain / drug effects Cocaine / antagonists & inhibitors, pharmacology* Conditioning, Classical / drug effects* Corticosterone / blood* Dizocilpine Maleate / pharmacology Injections, Intraperitoneal Male Motor Activity / drug effects Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate / drug effects* Social Environment |
| Grant Support | |
ID/Acronym/Agency:
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R01DA05366-09/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, N-Methyl-D-Aspartate; 50-22-6/Corticosterone; 50-36-2/Cocaine; 77086-22-7/Dizocilpine Maleate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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