| Evidence of intact histatins in the in vivo acquired enamel pellicle. | |
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MedLine Citation:
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PMID: 20351356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the composition and function of the acquired enamel pellicle (AEP) has been a major goal in oral biology. The aim of this study was to test the hypothesis that intact histatins are part of the in vivo AEP and that histatins after adsorption to HA have effects on in vitro enamel demineralization. This is the first study demonstrating the presence of intact histatins in vivo in the AEP. The in vitro experiments show that all naturally occurring histatins in the AEP have the potential to provide some level of protection against acid injury. |
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Authors:
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W L Siqueira; H C Margolis; E J Helmerhorst; F M Mendes; F G Oppenheim |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-03-29 |
Journal Detail:
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Title: Journal of dental research Volume: 89 ISSN: 1544-0591 ISO Abbreviation: J. Dent. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-06-11 Revised Date: 2011-10-17 |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 626-30 Citation Subset: D; IM |
Affiliation:
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Schulich Dentistry and Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Adult Calcium / analysis Dental Enamel / drug effects, metabolism Dental Pellicle / chemistry* Electrophoresis, Polyacrylamide Gel Female Histatins / analysis*, pharmacokinetics, therapeutic use Humans Male Microradiography Parotid Gland / secretion Phosphates / analysis Salivary Proteins and Peptides / analysis Secretory Rate / physiology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tooth Demineralization / prevention & control Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DE05672/DE/NIDCR NIH HHS; DE07652/DE/NIDCR NIH HHS; DE15163/DE/NIDCR NIH HHS; DE17788/DE/NIDCR NIH HHS; DE18132/DE/NIDCR NIH HHS; R01 DE005672-27/DE/NIDCR NIH HHS; R01 DE007652-22/DE/NIDCR NIH HHS; R01 DE007652-24/DE/NIDCR NIH HHS; R01 DE015163-05/DE/NIDCR NIH HHS; R21 DE018132-02/DE/NIDCR NIH HHS; U01 DE017788-04/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HTN3 protein, human; 0/Histatins; 0/Phosphates; 0/Salivary Proteins and Peptides; 101056-53-5/HTN1 protein, human; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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