Document Detail


Evidence for efficient vertical transfer of maternal HIV-1 envelope-specific neutralizing antibodies but no association of such antibodies with reduced infant infection.
MedLine Citation:
PMID:  23774880     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
: Little is known about the efficiency of vertical transfer of HIV-1-specific antibodies. Antibody levels in plasma from 60 mother-infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r = 0.91, P < 0.0001) and similar (1.4-fold greater in maternal plasma) between a mother and her corresponding infant as were the neutralizing antibody (Nab) levels (r = 0.80, P < 0.0001; 1.3-fold higher), suggesting efficient transfer. There was no significant difference in Nab responses between transmitting and nontransmitting mothers, although there was a trend for transmitting mothers to have higher HIV-1-specific Nabs.
Authors:
Maxwel M Omenda; Caitlin Milligan; Katherine Odem-Davis; Ruth Nduati; Barbra A Richardson; John Lynch; Grace John-Stewart; Julie Overbaugh
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  64     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-17     Completed Date:  2013-11-13     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Neutralizing / blood*,  immunology
Antibody Specificity
Breast Feeding / adverse effects
Female
HIV Antibodies / blood*,  immunology
HIV Infections / immunology*,  transmission,  virology
HIV-1 / immunology*
Humans
Immunity, Maternally-Acquired*
Infant
Infectious Disease Transmission, Vertical* / prevention & control
Kenya
Neutralization Tests
Pregnancy
Pregnancy Complications, Infectious / immunology*,  virology
env Gene Products, Human Immunodeficiency Virus / immunology
Grant Support
ID/Acronym/Agency:
AI076105/AI/NIAID NIH HHS; D43 TW000007/TW/FIC NIH HHS; D43 TW000007/TW/FIC NIH HHS; K24 HD054314/HD/NICHD NIH HHS; R01 AI076105/AI/NIAID NIH HHS; T32 AI083203/AI/NIAID NIH HHS; T32 AI083203/AI/NIAID NIH HHS; T32 GM007266/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Neutralizing; 0/HIV Antibodies; 0/env Gene Products, Human Immunodeficiency Virus
Comments/Corrections

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