| Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study. | |
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MedLine Citation:
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PMID: 22315322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine whether obese adolescents with high-"normal" 2-h post-oral glucose tolerance test glucose levels display defects in insulin secretion and sensitivity associated with future development of impaired glucose tolerance (IGT). Insulin sensitivity was measured by hyperinsulinemic-euglycemic clamp and insulin secretion by applying mathematical modeling during the hyperglycemic clamp in 60 normal glucose tolerance (NGT) obese adolescents, divided into three groups based on the 2-h glucose values (<100, 100-119, 120-139 mg/dL), and in 21 IGT obese adolescents. Glucose tolerance was reevaluated after 2 years. Insulin sensitivity decreased significantly across 2-h glucose NGT categories, while the highest NGT category and IGT group were similar. First-phase insulin secretion decreased across NGT categories, while no difference was found between the highest NGT group and IGT subjects. Second-phase secretion was similar across all NGT and IGT groups. The disposition index ((C)DI) decreased across NGT categories, while no difference was observed between the highest NGT and IGT subjects. Age and (C)DI were the best predictors of 2-h glucose after two years. Across rising categories of normal 2-h glucose levels, NGT obese adolescents exhibit significant impairment of β-cell function relative to insulin sensitivity associated with the development of IGT. |
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Authors:
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Cosimo Giannini; Ram Weiss; Anna Cali; Riccardo Bonadonna; Nicola Santoro; Bridget Pierpont; Melissa Shaw; Sonia Caprio |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-02-07 |
Journal Detail:
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Title: Diabetes Volume: 61 ISSN: 1939-327X ISO Abbreviation: Diabetes Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-22 Completed Date: 2012-04-10 Revised Date: 2012-04-30 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 606-14 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Cohort Studies Cross-Sectional Studies Female Glucose / metabolism* Glucose Tolerance Test Humans Insulin / secretion* Insulin Resistance* Longitudinal Studies Male Obesity / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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K24-HD-01464/HD/NICHD NIH HHS; R01-HD-28016/HD/NICHD NIH HHS; R01-HD-40787/HD/NICHD NIH HHS; UL1-RR-024139/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin; 50-99-7/Glucose |
| Comments/Corrections | |
Comment In:
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Diabetes. 2012 Mar;61(3):562-3
[PMID:
22354930
]
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Erratum In:
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Diabetes. 2012 Apr;61(4):967 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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