Document Detail


Update: Use of platelet glycoprotein IIb/IIIa inhibitors in patients with unstable angina and non-ST-segment elevation myocardial infarction.
MedLine Citation:
PMID:  20646787     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
DATA SOURCES: Searches were conducted of MEDLINE (1966 to 2006), EMBASE (1980 to April 2006), and the Cochrane's CENTRAL register (Issue 2, 2006), and hand-searched information from cardiology conferences, principal investigators of identified trials, pharmaceutical manufacturers, and other experts in the field were used. There were no language restrictions. STUDY SELECTION: Randomized controlled trials enrolling patients with non-ST-segment elevation acute coronary syndromes who initially received GPIIb/IIa inhibitors as part of the early medical management were eligible. DATA EXTRACTION AND SYNTHESIS: Primary outcomes were 30-day and 6-month mortality and the subsequent development of myocardial infarction; the secondary endpoint was major hemorrhage, defined as intracranial bleeding or any bleeding with a decrease in hemoglobin of greater than 5 g/dL or a greater than 15% reduction in hematocrit level. Data were reported as odds ratios (ORs) with a fixed-effect model if minimal heterogeneity was identified; otherwise, a random-effects model was used. All analyses were presented as intention to treat.
Authors:
Maude Latulippe; Eddy S Lang
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Publication Detail:
Type:  Comment; Journal Article     Date:  2010-06-19
Journal Detail:
Title:  Annals of emergency medicine     Volume:  56     ISSN:  1097-6760     ISO Abbreviation:  Ann Emerg Med     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1-2     Citation Subset:  -    
Copyright Information:
Copyright © 2010 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.
Affiliation:
University of Calgary, Faculty of Medicine, Division of Emergency Medicine Foothills Medical Centre, Calgary, Alberta, Canada.
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Comments/Corrections
Comment On:
Cochrane Database Syst Rev. 2010;(9):CD002130   [PMID:  20824831 ]

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