Document Detail

Evidence for 2-hydroxy-4(methylthio) butanoic acid and DL-methionine having different dose responses in growing broilers.
MedLine Citation:
PMID:  16903471     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to compare the gain-response curve to dietary levels of 2-hydroxy-4(methylthio) butanoic acid (HMTBA) and DL-Met (DLM) across 4 floor pen trials in which different diets were used. Six replicates of 38 or 41 birds per pen (trials 1 to 2 and 3 to 4, respectively) were used in a 2 x 3 factorial arrangement. A control with 12 replicates was also included. The 2 Met sources were fed at 3 equimolar levels equally spaced, with the highest level added at requirements from 1 to 48, 49, 43, or 49 d for trials 1, 2, 3, and 4, respectively. Commercial-type TSAA-deficient control diets contained sorghum, wheat, corn, or corn plus meat and bone meal for trials 1, 2, 3, and 4, respectively. Performance improved at all times for most parameters after supplementing with HMTBA or DLM (P < 0.05). No differences were found in the birds fed HMTBA or DLM at any age and trial (P > 0.05), except for trial 1, in which 17-d-old birds performed better when fed HMTBA than DLM (P < 0.05). In each trial, linear, quadratic, and exponential regressions were conducted upon the gain response of birds fed HMTBA and DLM separately. Equations with better goodness of fit were used to compare the estimated gain responses to feeding HMTBA vs. DLM. In 3 trials, the shape of the gain-response curve differed when feeding HMTBA vs. DLM. In trials 3 and 4, feeding HMTBA at commercial levels resulted in greater gain responses than DLM (P < 0.05), whereas, in trials 2 and 4, at very deficient levels, DLM-fed birds outperformed those fed HMTBA (P < 0.05). When the 4 trials were combined, the dose-response curve with the best goodness of fit was linear for HMTBA and quadratic for DLM. It can be concluded that the 2 Met sources have a different dose-response form, HMTBA could outperform DLM at commercial levels, and DLM could outperform HMTBA at deficient levels.
M Vázquez-Añón; R González-Esquerra; E Saleh; T Hampton; S Ritcher; J Firman; C D Knight
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  85     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-09-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1409-20     Citation Subset:  IM    
Novus International Inc., St Charles, MO 63304, USA.
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MeSH Terms
Animal Nutritional Physiological Phenomena
Chickens / growth & development*,  metabolism
Dose-Response Relationship, Drug
Methionine / administration & dosage*,  analogs & derivatives*,  chemistry,  metabolism
Nutritional Requirements*
Nutritional Status*
Random Allocation
Weight Gain / drug effects
Reg. No./Substance:
583-91-5/alpha-hydroxy-gamma-methylmercaptobutyric acid; 63-68-3/Methionine
Comment In:
Poult Sci. 2006 Dec;85(12):2047   [PMID:  17135657 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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