Document Detail

Everolimus causing severe hypertriglyceridemia and acute pancreatitis.
MedLine Citation:
PMID:  23307976     Owner:  NLM     Status:  MEDLINE    
Everolimus is an mTOR inhibitor commonly used to treat metastatic pancreatic neuroendocrine tumors (pNETs) and renal cell carcinoma, and for posttransplant immunosuppression. This report presents a case of a 36-year-old man being treated with everolimus for a metastatic pNET who developed severe hypertriglyceridemia and acute pancreatitis. The incidence of hypertriglyceridemia reported in large prospective randomized trials is reviewed and the management of hypertriglyceridemic pancreatitis is discussed. Careful monitoring of triglyceride levels and dose adjustments of everolimus together with lipid-lowering therapy can allow patients to continue this medication. Because there are increasing indications for the use of everolimus, prescribing oncologists must be cognizant of the common and serious side effects.
Somasundaram Subramaniam; Jason A Zell; Pamela L Kunz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the National Comprehensive Cancer Network : JNCCN     Volume:  11     ISSN:  1540-1413     ISO Abbreviation:  J Natl Compr Canc Netw     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-11     Completed Date:  2013-07-08     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  101162515     Medline TA:  J Natl Compr Canc Netw     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
Stanford Cancer Institute, Stanford, California, USA.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Hypertriglyceridemia / chemically induced*
Neuroendocrine Tumors / drug therapy*
Pancreatic Neoplasms / drug therapy*
Pancreatitis / chemically induced*
Sirolimus / adverse effects,  analogs & derivatives*
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents; 159351-69-6/everolimus; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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