Document Detail

Event-related potentials in schizotypal personality disorder.
MedLine Citation:
PMID:  8845699     Owner:  NLM     Status:  MEDLINE    
This study examined whether abnormalities in event-related potentials (ERPs), reported in schizophrenia, extend to patients with schizotypal personality disorder (SPD). Auditory ERPs in an oddball paradigm were obtained in 19 SPD patients, 17 schizophrenic patients, and 20 normal control subjects (NCs). Schizophrenic patients had lower P300 amplitude than NCs; the P300 amplitude of SPD patients was intermediate, showing a linear trend but not a significant group difference. P200 amplitudes showed a similar trend. SPD patients had N100 and N200 amplitudes intermediate to schizophrenic patients and NCs, without significant group differences. Results suggest diminished P300 amplitude may not be as prominent in SPD as in schizophrenia. Studies with larger sample sizes, multiple lead assessment strategies, and more demanding tasks may further characterize ERP deficits in schizophrenia-spectrum disorders such as SPD.
R L Trestman; T Horvath; O Kalus; A E Peterson; E Coccaro; V Mitropoulou; S Apter; M Davidson; L J Siever
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuropsychiatry and clinical neurosciences     Volume:  8     ISSN:  0895-0172     ISO Abbreviation:  J Neuropsychiatry Clin Neurosci     Publication Date:  1996  
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8911344     Medline TA:  J Neuropsychiatry Clin Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-40     Citation Subset:  IM    
Bronx Veterans Affairs Medical Center, New York, USA.
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MeSH Terms
Event-Related Potentials, P300 / physiology*
Psychiatric Status Rating Scales
Schizophrenia / physiopathology
Schizotypal Personality Disorder / physiopathology*,  psychology
Grant Support

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