| Event-related potentials in Parkinson's disease. | |
| | |
MedLine Citation:
|
PMID: 8803493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The increasingly recognized occurrence of dementia in Parkinson's disease (PD) has prompted study of cognitive evoked potentials in this disorder. The P300 wave is related to cognitive performance, while the contingent negative variation (CNV) may reflect dopaminergic function. We measured P300 and CNV in 21 nondemented PD patients and compared them to elderly controls. The P300 was recorded from Cz with linked ear reference. 3,000 and 1,000 Hz tones were presented in an 80:20 ratio at 76 dBSL interstimulus interval was 1.1 seconds, and filter bandpass was 1-100 Hz. CNV recording utilized a 2000 Hz tone followed after 1.5 seconds by a light flash and button press, and was recorded from Fz with linked ear reference, 10-second analysis time, and 0.1-20 Hz filter bond pass. N200 and P300 amplitudes were significantly longer and latency significantly lower in PD patients than in controls, and P300 latency was correlated with composite score on cognitive tests. CNV amplitude was significantly reduced in PD patients, but was correlated with measures of motor disability rather than cognition. These findings suggest that bradyphrenia may occur in nondemented PD patients, and that P300 may measure cognitive changes in PD. CNV may be a dopaminergic slow potential and may correlate with motor function in nondemented PD patients. |
| | |
Authors:
|
A Aotsuka; S J Weate; M E Drake; G W Paulson |
Related Documents
:
|
2586763 - Experience with continuous enteral levodopa infusions in the treatment of 9 patients wi... 3352903 - Focal task-specific tremor and dystonia: categorization of occupational movement disord... 15557833 - Does famotidine induce thrombocytopenia in neurosurgical patients? |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Electromyography and clinical neurophysiology Volume: 36 ISSN: 0301-150X ISO Abbreviation: Electromyogr Clin Neurophysiol Publication Date: 1996 Jun |
Date Detail:
|
Created Date: 1997-03-28 Completed Date: 1997-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0327533 Medline TA: Electromyogr Clin Neurophysiol Country: BELGIUM |
Other Details:
|
Languages: eng Pagination: 215-20 Citation Subset: IM |
Affiliation:
|
Ohio State University Hospitals, Department of Neurology, Ohio State University College of Medicine, Columbus, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Electroencephalography Event-Related Potentials, P300 / physiology* Female Humans Male Middle Aged Parkinson Disease / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Follow-up study on F-wave in patients with lumbosacral radiculopathy. Comparison between before and ...
Next Document: The behavior of rectus femoris and vastus lateralis during fatigue and recovery: an electromyographi...