Document Detail

Event-related potentials (P300) and EEG activity in childhood partial epilepsy.
MedLine Citation:
PMID:  9105657     Owner:  NLM     Status:  MEDLINE    
To clarify the relationship between the cognitive function and EEG activity, auditory event-related potentials (P300) were examined in 72 patients with partial epilepsy. Twenty-six patients (67 trials) had idiopathic partial epilepsies (IPE), and 46 (118 trials) symptomatic or cryptogenic partial epilepsies (SPE). For this study, patients undergoing carbamazepine monotherapy with a dose of less than 16 mg/kg/day were selected to rule out the effects of anti-epileptic drugs. The results were as follows: (1) The P300 latency tended to be prolonged in association with the EEG slowing in both epileptic groups. (2) There was no clear relationship between the frequency of paroxysmal discharges and the P300 latency. (3) The P300 latency was slightly prolonged in the patients with temporal foci compared with that in ones with extra-temporal foci. (4) There was no significant relationship between the generalization of focal paroxysmal discharges and the P300 latency. These results suggested that the influence of EEG abnormalities (particularly paroxysmal discharges) on the P300 latency is relatively little, and the cognitive dysfunction in partial epilepsies mainly originates from other factors such as the epileptogenic lesion itself.
Y Naganuma; T Konishi; K Hongou; T Okada; J Tohyama; M Uchiyama
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  19     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-26     Completed Date:  1997-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Aging / physiology
Anticonvulsants / therapeutic use
Carbamazepine / therapeutic use
Child, Preschool
Cognition / physiology
Electroencephalography* / drug effects
Epilepsies, Partial / drug therapy,  physiopathology*,  psychology
Event-Related Potentials, P300 / drug effects,  physiology*
Evoked Potentials, Auditory / drug effects,  physiology
Reg. No./Substance:
0/Anticonvulsants; 298-46-4/Carbamazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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