| Event related oscillations in euthymic patients with bipolar disorder. | |
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MedLine Citation:
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PMID: 18687385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bipolar disorder involves dysfunction in gamma amino butyric acid (GABA)/glutamatergic systems and neural circuits that regulate cognitive processing. Valproate, a mood stabilizing anticonvulsant, modulates GABA/glutamate and shows neuroprotective effect. Electroencephalographic oscillatory activity assessment is an alternative brain imaging technique with high time resolution. It presents integrative brain functioning. We aimed to assess the oscillatory responses of patients with bipolar disorder in euthymic state of bipolar disorder and the changes after treatment with valproate. Event related potentials to visual odd-ball paradigm in 10 euthymic medication free, bipolar patients were measured before and after 6 weeks of valproate monotherapy and compared with sex- and age-matched healthy controls. Delta frequency bands, as representative of signal detection and decision-making, were obtained by digital filtering. At baseline, patients showed higher delta responses to target stimuli in all but significantly left frontal channels in comparison to controls. After 6 weeks of treatment, delta responses decreased significantly in central frontal (Fz) (p: 0.028), left frontal (F3) (p: 0.028), left (T3) (p: 0.015), right anterior (T4) (p: 0.011), and left posterior temporal (T5) (p: 0.011) channels compared to baseline and became no different to the controls, which did not differ between two assessments. The findings point to a diffuse increase in low frequency electrical activity which was prominent in the left frontal location in euthymic patients with bipolar disorder. Reduction of the electrical activity of the left frontal and bilateral anterior temporal areas with treatment may be through modulation of glutamatergic and GABAergic mechanisms and indicative of valproate's neuroprotective effect. |
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Authors:
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Ayşegül Ozerdem; Sibel Kocaaslan; Zeliha Tunca; Erol Başar |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2008-08-05 |
Journal Detail:
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Title: Neuroscience letters Volume: 444 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2009-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 5-10 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Dokuz Eylul University Medical School, Narlidere, 35340, Izmir, Turkey. aysegul.ozerdem@deu.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antimanic Agents / pharmacology, therapeutic use Bipolar Disorder / drug therapy, pathology*, physiopathology, psychology* Brain / physiopathology* Brain Mapping Evoked Potentials, Visual / drug effects, physiology* Female Humans Male Middle Aged Photic Stimulation / methods Valproic Acid / pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antimanic Agents; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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