Document Detail

Event related oscillations in euthymic patients with bipolar disorder.
MedLine Citation:
PMID:  18687385     Owner:  NLM     Status:  MEDLINE    
Bipolar disorder involves dysfunction in gamma amino butyric acid (GABA)/glutamatergic systems and neural circuits that regulate cognitive processing. Valproate, a mood stabilizing anticonvulsant, modulates GABA/glutamate and shows neuroprotective effect. Electroencephalographic oscillatory activity assessment is an alternative brain imaging technique with high time resolution. It presents integrative brain functioning. We aimed to assess the oscillatory responses of patients with bipolar disorder in euthymic state of bipolar disorder and the changes after treatment with valproate. Event related potentials to visual odd-ball paradigm in 10 euthymic medication free, bipolar patients were measured before and after 6 weeks of valproate monotherapy and compared with sex- and age-matched healthy controls. Delta frequency bands, as representative of signal detection and decision-making, were obtained by digital filtering. At baseline, patients showed higher delta responses to target stimuli in all but significantly left frontal channels in comparison to controls. After 6 weeks of treatment, delta responses decreased significantly in central frontal (Fz) (p: 0.028), left frontal (F3) (p: 0.028), left (T3) (p: 0.015), right anterior (T4) (p: 0.011), and left posterior temporal (T5) (p: 0.011) channels compared to baseline and became no different to the controls, which did not differ between two assessments. The findings point to a diffuse increase in low frequency electrical activity which was prominent in the left frontal location in euthymic patients with bipolar disorder. Reduction of the electrical activity of the left frontal and bilateral anterior temporal areas with treatment may be through modulation of glutamatergic and GABAergic mechanisms and indicative of valproate's neuroprotective effect.
Ayşegül Ozerdem; Sibel Kocaaslan; Zeliha Tunca; Erol Başar
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2008-08-05
Journal Detail:
Title:  Neuroscience letters     Volume:  444     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
Department of Psychiatry, Dokuz Eylul University Medical School, Narlidere, 35340, Izmir, Turkey.
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MeSH Terms
Antimanic Agents / pharmacology,  therapeutic use
Bipolar Disorder / drug therapy,  pathology*,  physiopathology,  psychology*
Brain / physiopathology*
Brain Mapping
Evoked Potentials, Visual / drug effects,  physiology*
Middle Aged
Photic Stimulation / methods
Valproic Acid / pharmacology,  therapeutic use
Reg. No./Substance:
0/Antimanic Agents; 99-66-1/Valproic Acid

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