Document Detail

Event-related fMRI in cognition.
MedLine Citation:
PMID:  21963919     Owner:  NLM     Status:  MEDLINE    
A primary advantage of functional magnetic resonance imaging (fMRI) over other techniques in neuroscience is its flexibility. Researchers have used fMRI to study a remarkable diversity of topics, from basic processes of perception and memory, to the complex mechanisms of economic decision making and moral cognition. The chief contributor to this experimental flexibility-indeed, to the growth of fMRI itself-has been the development of event-related experimental designs and associated analyses. The core idea of an event-related design, as first articulated in the late 1990s, is the separation of cognitive processes into discrete points in time (i.e., "events") allowing differentiation of their associated fMRI signals. By modeling brain function as a series of transient changes, rather than as an ongoing state, event-related fMRI allowed researchers to create much more complex paradigms and more dynamic analysis methods. Yet, this flexibility came with a cost. As the complexity of experimental designs increased, fMRI analyses became increasingly abstracted from the original data, which in turn has had consequences both positive (e.g., greater use of model-based fMRI) and negative (e.g., fewer articles plot the timing of activation). And, as event-related methods have become ubiquitous, they no longer represent a distinct category of fMRI research. In a real sense, event-related fMRI has now become, simply, fMRI.
Scott A Huettel
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-22
Journal Detail:
Title:  NeuroImage     Volume:  62     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-11-19     Revised Date:  2013-08-19    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1152-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA.
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MeSH Terms
Brain Mapping* / history,  methods
Cognition / physiology*
Evoked Potentials / physiology
History, 20th Century
History, 21st Century
Magnetic Resonance Imaging* / history,  methods
Grant Support
NIMH RC1-88680/RC/CCR NIH HHS; NINDS P01-41328//PHS HHS; P01 NS041328-10/NS/NINDS NIH HHS; RC1 MH088680-02/MH/NIMH NIH HHS

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