Document Detail


Event-related brain potentials during an extended visual recognition memory task depict delayed development of cerebral inhibitory processes among 6-month-old infants with Down syndrome.
MedLine Citation:
PMID:  9664227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of cerebral inhibitory processes among individuals with Down syndrome (DS) may be delayed at an early age. In support of this hypothesis, sensory-evoked potentials (EPs) and event-related brain potentials (ERPs) have previously delineated altered habituation to stimuli among infants with DS. The purpose of the current study was to provide extended experience with visual stimuli among 6-month-old infants with and without DS (nDS) to determine if altered ERP and behavioral response decrements would be evident even after repeated presentations of stimuli. An 80/20% oddball paradigm was employed. Infants with DS and nDS were matched according to age and gender. Infants with DS demonstrated significantly larger Nc areas, Nc peak amplitudes, Nc2 areas and, inversely, significantly smaller peak Pb amplitudes when compared to infants nDS. Contrasts of the two study groups were most robust within ERP measures from frontal (Fz) and parietal (Pz) recording sites. Infants with DS also demonstrated a significantly slower decrement of most ERP components with repetitive stimulus experience. Most noteworthy was the observation of little or no decrement of ERP components at Fz among infants with DS. Both infants with DS and nDS demonstrated significantly larger Nc peak amplitudes, Nc areas, Nc2 areas, Pb peak amplitudes and NSW areas to rare stimuli. While significant probability and experiential trends were observed in visual fixation measures across both study groups, there were no significant differences of visual attention between infants with DS or nDS. These data demonstrate the value of ERPs within the study of atypical cognitive development during infancy and support the concept of altered inhibitory processes in the brain of infants with DS.
Authors:
J H Karrer; R Karrer; D Bloom; L Chaney; R Davis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of psychophysiology : official journal of the International Organization of Psychophysiology     Volume:  29     ISSN:  0167-8760     ISO Abbreviation:  Int J Psychophysiol     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-01     Completed Date:  1998-10-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8406214     Medline TA:  Int J Psychophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  167-200     Citation Subset:  IM    
Affiliation:
University of Kansas Medical Center, Smith Mental Retardation and Human Development Research Center, Kansas City, MO, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain / physiopathology*
Child Psychology
Cognition / physiology*
Developmental Disabilities / physiopathology,  psychology*
Down Syndrome / physiopathology,  psychology*
Evoked Potentials, Visual / physiology*
Female
Fixation, Ocular / physiology
Humans
Infant
Male
Memory / physiology*
Photic Stimulation
Grant Support
ID/Acronym/Agency:
NICHD 30868/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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