Document Detail

Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly.
MedLine Citation:
PMID:  17634702     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Moderate to high intensity exercise training is known to ameliorate the coronary risk factors in relation to an improvement in body composition. However, the benefit of low-intensity and low-volume training for these risk factors remains unclear in elderly people. Therefore, we investigated the effects of low-intensity and low-volume exercise training on blood lipid values and insulin resistance in the elderly. METHODS: A total of 56 healthy elderly individuals (42 females and 14 males) aged 64+/-6 years participated in a 12-week exercise program, comprising aerobic training and resistance training. RESULTS: After the program, there were no significant changes in high-density lipoprotein cholesterol, triglyceride serum levels, or in peak oxygen uptake on average. However, the homeostasis of minimal assessment of insulin resistance (HOMA-IR) value was significantly reduced by 21%. The participants were categorized into tertiles based on initial Body Mass Index (BMI). The Middle-BMI group (non-obese subjects) showed reduced HOMA-IR (2.0-->1.3, P<0.01), but this reduction was not associated with the reduction in BMI (r=0.08, P=0.74), whereas the two reductions were significantly associated in the High-BMI group (r=0.61, P=0.01). CONCLUSION: Even low-intensity and low-volume exercise training, which would ordinarily be insufficient for improving mean lipid values or aerobic fitness, was found to be effective in improving insulin resistance in the elderly. The improvement in insulin resistance was independent of the improvement in obesity.
Satoru Kodama; Miao Shu; Kazumi Saito; Haruka Murakami; Kiyoji Tanaka; Shinya Kuno; Ryuichi Ajisaka; Yasuko Sone; Fumiko Onitake; Akimitsu Takahashi; Hitoshi Shimano; Kazuo Kondo; Nobuhiro Yamada; Hirohito Sone
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-17
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  46     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1071-7     Citation Subset:  IM    
Department of Internal Medicine, University of Tsukuba.
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MeSH Terms
Aged / physiology*
Blood Pressure
Body Composition / physiology
Exercise / physiology*
Insulin Resistance / physiology*
Lipids / blood
Middle Aged
Oxygen Consumption / physiology
Physical Fitness / physiology
Sex Factors
Reg. No./Substance:

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