Document Detail


Evaporation and skin penetration characteristics of mosquito repellent formulations.
MedLine Citation:
PMID:  2565367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Formulations of the mosquito repellent N,N-diethyl-3-methylbenzamide (deet) in combination with a variety of additives were developed to control repellent evaporation and percutaneous penetration. Deet was also formulated with the repellent dimethyl phthalate to study the interaction of the two compounds on the skin. The evaporation and penetration processes were evaluated on whole and split-thickness pig skin using radiolabeled repellents with an in vitro apparatus. Under essentially still air and air flow conditions, one of the deet formulations resulted in significantly reduced total evaporation and percutaneous penetration of deet as compared to unformulated repellent. When deet and dimethyl phthalate were combined, neither repellent affected the total amount of evaporation and penetration of the other compound. However, initial percutaneous penetration and evaporation rates were slightly less and decayed less rapidly than when both chemicals were tested separately at the same dose. These results indicated a degree of competition of the two compounds for the same avenues of loss.
Authors:
W G Reifenrath; G S Hawkins; M S Kurtz
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of the American Mosquito Control Association     Volume:  5     ISSN:  8756-971X     ISO Abbreviation:  J. Am. Mosq. Control Assoc.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-07     Completed Date:  1989-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8511299     Medline TA:  J Am Mosq Control Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
Affiliation:
Division of Cutaneous Hazards, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.
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MeSH Terms
Descriptor/Qualifier:
Acrylates
Animals
Benzamides / administration & dosage*
Carbon Radioisotopes / diagnostic use
Culicidae
DEET / administration & dosage*,  analysis,  pharmacokinetics
Fatty Acids
Humans
Phthalic Acids
Silicones
Skin / analysis,  metabolism
Skin Absorption*
Swine
Vehicles
Volatilization
Chemical
Reg. No./Substance:
0/Acrylates; 0/Benzamides; 0/Carbon Radioisotopes; 0/Fatty Acids; 0/Phthalic Acids; 0/Silicones; 0/Vehicles; 131-11-3/dimethyl phthalate; 134-62-3/DEET

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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